Assessment of Exposure-Response Functions for Rocket-Emission Toxicants
National Academies Press, Jul 28, 1998 - Medical - 208 pages
The U.S. Air Force is developing a model to assist commanders in determining when it is safe to launch rocket vehicles. The model estimates the possible number and types of adverse health effects for people who might be exposed to the ground cloud created by rocket exhaust during a normal launch or during an aborted launch that results in a rocket being destroyed near the ground.
Assessment of Exposure-Response Functions for Rocket-Emmission Toxicants evaluates the model and the data used for three rocket emission toxicants: hydrogen chloride, nitrogen dioxide, and nitric acid.
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Definition of Severity of Effects
SUBPOPULATIONS SENSITIVE TO AIR CONTAMINATION
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5-min LCso ACGIH acid aerosol airway resistance airway responsiveness animals associated asthmatic asthmatic subjects BAL fluid CEGL ceiling concen COPD Darmer decrease developed dose dose-response EEGL effect level emissions ERFs estimate evaluate expo exposed to HCl exposure concentrations exposure duration exposure levels exposure limit guinea pigs Haber's rule hazard-quotient HCl exposure health effects healthy individuals HNO3 humans hydrogen chloride IDLH increase inhalation irritation Januszkiewicz LATRA model LATRA-ERF model Lehnert lung macrophages Mayorga mice mild effects moderate mortality Mouse nasal NIOSH nitrogen dioxide NOEL normal populations ppm End Points probit probit model pulmonary edema pulmonary function rats recommendations REEDM reported respiratory rate respiratory tract risk rocket rocket-emission toxicants sensitive and normal sensitive humans sensitive individuals sensitive populations sensitive subgroups severe effects severity categories severity of effect sheep short-term specific SPEGL studies subcommittee threshold tier limits tions toxicity Toxicology tration U.S. Air Force uncertainty values