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Antihistamine properties of astemizole during histamine challenge
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active administration adults allergen allergen challenge Allergy Clin Immunol anticholinergic antihistamines astemizole 10 mg astemizole and placebo astemizole group Astemizole in asthma astemizole treatment asthmatic patients azelastine baseline betamethasone bronchial asthma bronchoconstriction bronchodilator cetirizine chlorpheniramine clemastine clinical Clive Wood Congress and Symposium difference dose double-blind drug dyspnoea effect of astemizole evaluation exercise exercise-induced asthma fall in FEVj histamine concentration Holgate ST Hrreceptor antagonist Hrreceptor blockade hyperventilation hyperventilation challenge increased inhalation challenge inhibition investigator Janssen Janssen Pharmaceutica ketotifen loratadine maintenance therapy mast cells mediators medication Medicine Services International Medicine Services Limited methacholine mg astemizole mg/kg mg/ml non-sedative oral oxatomide PC2o histamine Pharmacol pharmacological placebo placebo group placebo-controlled potent published by Royal pulmonary reaction receptor Royal Society Services International Congress side-effects significant significantly skin tests Society of Medicine Symposium Series symptoms terfenadine therapeutic treatment period treatment with astemizole urticaria Vanden Bussche G weeks of treatment wheal and flare