Asthma: Critical DebatesSebastian L. Johnston, Stephen T. Holgate Asthma is one of the most important diseases affecting our society. It is an extremely common condition that reduces quality of life, and acute exacerbations can be life-threatening. It affects a disproportionate number of children. With the overwhelming volume of research being carried out in this field specialists need a method of keeping up-to-date with current opinion. As with the other 'Challenges' books, 'Challenges in Asthma' is aimed at hospital specialists and therefore assumes a certain level of knowledge about the disease. It builds on this by discussing only areas of controversy and uncertainty in both the basic understanding of asthma and its management. An international author list will provide stimulating debate with, and ultimately draw some conclusions from, existing data which will benefit readers in their day-to-day practice. |
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activation adults air pollution airway airway inflammation airway responsiveness allele allergen allergen exposure allergen levels Allergy Allergy Clin Immunol antibodies antigen associated asthma and atopy asthma clinic asthmatic patients atopic disease atopy beclometasone Biol bronchial hyperresponsiveness bronchoconstriction bronchodilator budesonide childhood asthma chromosome chronic Clin Exp Allergy cohort collagen COPD cytokine diagnosis dose East Germany effects environmental eosinophil evidence exacerbations FEV1 fibroblasts fibrosis formoterol gene genetic glucocorticoid hay fever hospital house dust mite human IgE levels increase indoor induced infection inflammatory inhaled corticosteroids inhibit interleukin Lancet leukotriene modifiers linkage long-acting b-agonists lung function maternal medication MedJ mite allergen montelukast obstruction patients with asthma peak flow Pediatr phenotype placebo pneumoniae polymorphism population prevalence of asthma primary pulmonary receptor reduced Resp Crit respiratory symptoms Rev Resp risk factor role salbutamol salmeterol sensitization severe asthma significant smoking steroid studies T-cell therapy Thorax treatment viral wheezing zafirlukast