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Trends in Asthma Prevalence
Mortality from Asthma
The Pathology of Asthma
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acid activation adhesion molecules agonists airway airway hyperresponsiveness airway inflammation airway responsiveness airway smooth muscle allergen Allergy Allergy Clin antibodies antigen antigen challenge associated asthmatic patients asthmatic reactions asthmatic subjects atopic atopy Austen BAL fluid basophils biopsies blood BMMC bronchial bronchoconstriction Ca2+ cholinergic chronic clinical clones corticosteroid cytokines disease effect enhanced enzyme eosinophils epithelial cells epithelium exposure expression factor fenoterol fibroblasts function gene GM-CSF granule guinea pig histamine Holgate human mast cells IFN-y Immunol increase in airway induced infection infiltration inflammatory cells inhaled inhibit inhibitors interleukin intracellular J-agonists leucocyte leukotriene levels LTC4 lung lymphocytes lymphokines macrophages mast cells mechanisms mediator release membrane methacholine monocytes mouse mRNA mucosa nedocromil nerves neurones neutrophils normal occupational asthma peptide PGD2 phenotype Physiol potential production protease protein proteoglycans receptor Respir respiratory role salbutamol sensitized smooth muscle specific steroids stimulation studies suggest T-cell tissue treatment tryptase vitro vivo