Asymmetric Synthesis of Natural Products

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John Wiley & Sons, Jun 15, 2012 - Science - 328 pages
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Asymmetric Synthesis of Natural Products, 2nd Edition introduces students to this rapidly growing field of organic chemistry. The initial chapters present the foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions. This is followed by chapters on each of the major individual classes of natural products; their structures, biosynthesis and interrelationships as well as examples of asymmetric syntheses and the practical value of these compounds. Natural product classes covered include carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, polyketides, isoprenoids, shikamic acid derivatives and alkaloids.

For this second edition the text has been thoroughly updated and expanded, and includes new discussions and examples covering atom and redox economies, practical aspects and environmental awareness. Organocatalysis has emerged completely in the last ten years, and has been fully integrated into this new edition.

 

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Contents

21 The Need for Enantiopure Compounds
2-12
22 Determination of Enantiomeric Purity
2-16
23 Chirality and Thermodynamic Principles of Asymmetric Induction
2-20
24 Methods for Obtaining Chiral Compounds
2-22
References
2-32
31 Allylic Strain
2-36
32 Reactions of the Carbonyl Group
3-3
33 Reactions of Olefins
3-63
56 Asymmetric Synthesis of Amino Acids
5-19
References
5-30
References
5-42
71 Biosynthesis
5-45
72 Fatty Acids
5-47
73 Polypropionates
7-9
74 Aromatic Polyketides
7-25
References
7-28

References
3-72
41 Monosaccharides
4-1
42 Polysaccharides
4-12
43 Glycoproteins and Proteoglycans
4-16
44 Glycolipids
4-19
45 Sugar Antibiotics
4-20
46 Cyclitols
4-24
References
4-28
51 Amino Acids
5-1
52 Peptides and Proteins
5-6
53 Enzymes and Receptors
5-10
54 Chemical Modifications of Peptides
5-11
55 Biosynthesis of Amino Acids
5-13
81 Terpenes
8-2
82 Carotenoids
8-17
83 Steroids
8-19
References
8-28
Oseltamivir
8-34
References
8-37
101 Heterocyclic Alkaloids
8-40
102 Alkaloids with Exocyclic Nitrogen
10-26
103 Polyamine Alkaloids
10-28
105 Terpene Alkaloids
10-29
References
10-30
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About the author (2012)

Professor Ari M.P. Koskinen, Department of Chemistry, School of Science and Technology, Aalto University, Finland
Professor Koskinen has held academic appointments at the University of Sussex and University of Oulu , and transferred to his current position at Aalto University in 1999 as Professor of Organic Chemistry. He also holds docentships at the Universities of Helsinki and Turku. Professor Koskinen is a member of the Finnish Academy of Sciences and Letters, the Novartis Foundation International Scientific Advisory Panel, the Scientific Advisory Board of the Finnish Chemical Industry Federation, European Society for Combinatorial Sciences, on the management committees of EU-research programs, and is a founding member of the European Chemical Society. He is the author or co-author of some 160 publications, 15 patents and three books.

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