Atherosclerosis: Gene Expression, Cell Interactions, and Oxidation
R. T. Dean, David T. Kelly
Oxford University Press, 2000 - Medical - 450 pages
Provides a critical review of the oxidative theory of atherosclerosis as well as highlighting new trends in research from basic to clinical, academic to commercial. The contributions of diabetes, vascular dysfunction, blood coagulation, plaque rupture, oxidative stress, lymphocytes, macrophages, growth factors, cytokines, and oxysterols to atherogenesis are all discussed, as are the roles of smooth muscle and endothelial cells. As well as a summary of the methods of diagnosis, the future prospect of using biochemical markers from plasma is also discussed. There is a critical look at gene therapy and other future therapeutic strategies based on the molecular and cellular causes of atherosclerosis. Each chapter is written by two or more authors from different laboratories to ensure a balanced approach. It should be of use to all biomedical researchers with a specialist or passing interest in atherosclerosis research. This book is intended for biomedical researchers with a specialist or passing interest in atherosclerosis research.
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a-TOH accumulation activity adhesion molecules aggregation antigen antioxidants aorta aortic apolipoprotein Arterioscler artery wall associated atherogenesis atherogenic atherosclerosis atherosclerotic lesions binding Biochem Biol blood cardiovascular carotid caveolae cell adhesion cellular Chem cholesterol cholesterol efflux cholesteryl ester Circulation Clin clinical collagen coronary artery cytokines diabetes disease effects endothelial cells endothelial dysfunction endothelial function endothelium endothelium-dependent enhanced enzyme expression extracellular matrix fatty streaks foam cells formation gene therapy gene transfer glycation growth factor hydroperoxides increased induced inflammatory inhibition inhibitor interactions intima kinase levels lipid peroxidation low density lipoprotein low-density lipoprotein lymphocytes lysosomal macrophages mechanism mediated membrane metabolism mice monocytes myocardial Natl normal oxidation products oxidized LDL OxLDL oxysterols patients phospholipid plasma platelet potential proliferation protein oxidation proteoglycans rabbits radical reactions receptor response risk factors role SMCs smooth muscle cells specific stimulation studies superoxide Thromb thrombosis uptake vascular smooth muscle Vase vessel wall vitamin vitro vivo