Atlas of Hematologic Neoplasms

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Springer Science & Business Media, Jun 12, 2009 - Medical - 525 pages
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Due to its rapid development in recent years, hematopathology has become a very complicated discipline. The current development is mainly in two aspects: the new classification of lymphomas and leukemias and the new techniques.

The Revised European-American Classification of Lymphoid Neoplasms (REAL classification) and the World Health Organization (WHO) classification of hematologic neoplasms require not only morphologic criteria but also immunophenotyping and molecular genetics for the diagnosis of hematologic tumors. Immunophenotyping is performed by either flow cytometry or immunohistochemistry. There are many new monoclonal antibodies and new equipments accumulated in recent years that make immunophenotyping more or more accurate and helpful. There are even more new techniques invented in recent years in the field of molecular genetics. In cytogenetics, the conventional karyotype is supplemented and partly replaced by the fluorescence in situ hybridization (FISH) technique. The current development of gene expression profiling is even more powerful in terms of subtyping the hematologic tumors, which may help guiding the treatment and predict the prognosis. In molecular biology, the tedious Southern blotting technique is largely replaced by polymerase chain reaction (PCR). The recent development in reverse-transcriptase PCR and quantitative PCR makes these techniques even more versatile.

Because of these new developments, hematopathology has become too complicated to handle by a general pathologist. Many hospitals have to hire a newly trained hematopathologist to oversee peripheral blood, bone marrow and lymph node examinations. These young hematopathologists are geared to the new techniques, but most of them are inexperienced in morphology. No matter how well-trained a hematopathologist is, he or she still needs to see enough cases so that they can recognize the morphology and use the new techniques to substantiate the diagnosis. In other words, morphology is still the basis for the diagnosis of lymphomas and leukemias.

Therefore, a good color atlas is the most helpful tool for these young hematopathologists and for the surgical pathologists who may encounter a few cases of hematologic tumors from time to time. In a busy daily practice, it is difficult to refer to a comprehensive hematologic textbook all the time. There are a few hematologic color atlases on the market to show the morphology of the normal blood cells and hematologic tumor cells. These books are helpful but not enough, because tumor cell morphology is variable from case to case and different kinds of tumor cells may look alike and need to be differentiated by other parameters.

The best way to learn morphology is through the format of clinical case study. This format is also consistent with the daily practice of hematopathologists and with the pattern in all the specialty board examinations. Therefore, it is a good learning tool for the pathology residents, hematology fellows as well as medical students.

This proposed book will present 83 clinical cases with clinical history, morphology of the original specimen and a list of differential diagnoses. This is followed by further testing with pictures to show the test results. At the end, a correct diagnosis is rendered with subsequent brief discussion on how the diagnosis is achieved. A few useful references will be cited and a table will be provided for differential diagnosis in some cases.

The major emphasis is the provision of 500 color photos of peripheral blood smears, bone marrow aspirates, core biopsy, lymph node biopsy and biopsies of other solid organs that are involved with lymphomas and leukemias. Pictures of other diagnostic parameters, such as flow cytometric histograms, immunohistochemical stains, cytogenetic karyotypes, fluorescence in situ hybridization and polymerase chain reaction, will also be included.

A comprehensive approach with consideration of clinical, morphologic, immunophenotypic and molecular genetic aspects is the best way to achieve a correct diagnosis. After reading this book, the reader will learn to make a diagnosis not only based on the morphology alone but also in conjunction with other parameters.

 

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Contents

Introduction
3
Morphology of Hematopoietic Cells
8
Comparison Between Flow Cytometry and Immunohistochemistry
22
Cytogenetic Techniques for Hematologic Neoplasms
24
Molecular Biology Techniques for Hematologic Neoplasms
26
Diagnostic Procedures for Hematologic Neoplasms
27
Case Studies
32
Hematologic Neoplasms
33
Case 41
252
Case 42
259
Case 43
267
Case 44
273
Case 45
279
Case 46
286
Case 47
290
Case 48
296

Case 2
41
Case 3
45
Case 4
50
Case 5
57
Case 6
62
Case 7
68
Case 8
73
Case 9
80
Case 10
85
Case 11
91
Case 12
96
Case 13
101
Case 14
107
Case 15
112
Case 16
116
Case 17
120
Case 18
125
Case 19
129
Case 20
135
Case 21
141
Case 22
146
Case 23
152
Case 24
157
Case 25
161
Case 26
166
Case 27
172
Case 28
178
Case 29
184
Case 30
188
Case 31
194
Case 32
200
Case 33
204
Case 34
211
Case 35
218
Case 36
224
Case 37
228
Case 38
234
Case 39
241
Case 40
246
Case 49
301
Case 50
307
Case 51
314
Case 52
319
Case 53
323
Case 54
332
Case 55
339
Case 56
344
Case 57
349
Case 58
354
Case 59
361
Case 60
366
Case 61
370
Case 62
375
Case 63
381
Case 64
385
Case 65
393
Case 66
397
Case 67
402
Case 68
407
Case 69
415
Case 70
423
Case 71
430
Case 72
434
Case 73
439
Case 74
443
Case 75
451
Case 76
458
Case 77
466
Case 78
471
Case 79
475
Case 80
480
Case 81
488
Case 82
493
Case 83
497
Case 84
501
Case 85
507
Index
513
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