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abnormalities acute affected alopecia antibodies approximately areas arterial arthritis associated autosomal basal cell carcinomas biopsy bleeding bone bullae bullous caused characteristic characterized chronic clinical common commonly condition Crohn's disease crusts cutaneous cutaneous lesions cutaneous manifestations dermatitis diabetes diagnosis disorder drug edema eruption erythema extremities fever frequently gastrointestinal genital hair hemorrhagic hepatitis herpes herpes zoster histologic hyperpigmentation immunosuppressed indurated infection infiltration involvement Kaposi's sarcoma Kawasaki disease lupus erythematosus lymphoma macules malignancy melanoma metastases mucosa mucous membranes nail neck nevi nodes nodules occasionally occur in patients oral organism pain palms and soles papules patches patient in Figure patient shown patients develop percent of patients pigmented plaques present pruritic psoriasis pulmonary purpura pustules pyoderma gangrenosum rare rash Raynaud's phenomenon recurrent renal result revealed scalp scars scleroderma seen severe shown in Figure skin lesions squamous cell carcinomas steroids subcutaneous syndrome telangiectases tissue treatment trunk tumor ulcers usually vasculitis vesicles xanthomas