Atomic Force Microscopy in Liquid: Biological Applications

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John Wiley & Sons, May 14, 2012 - Science - 362 pages
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About 40 % of current atomic force microscopy (AFM) research is performed in liquids, making liquid-based AFM a rapidly growing and
important tool for the study of biological materials. This book focuses on the underlying principles and experimental aspects of AFM under
liquid, with an easy-to-follow organization intended for new AFM scientists. The book also serves as an up-to-date review of new AFM techniques developed especially for biological samples.
Aimed at physicists, materials scientists, biologists, analytical chemists, and medicinal chemists. An ideal reference book for libraries.

From the contents:

Part I: General Atomic Force Microscopy
* AFM: Basic Concepts
* Carbon Nanotube Tips in Atomic Force Microscopy with
* Applications to Imaging in Liquid
* Force Spectroscopy
* Atomic Force Microscopy in Liquid
* Fundamentals of AFM Cantilever Dynamics in Liquid
* Environments
* Single-Molecule Force Spectroscopy
* High-Speed AFM for Observing Dynamic Processes in Liquid
* Integration of AFM with Optical Microscopy Techniques

Part II: Biological Applications
* DNA and Protein-DNA Complexes
* Single-Molecule Force Microscopy of Cellular Sensors
* AFM-Based Single-Cell Force Spectroscopy
* Nano-Surgical Manipulation of Living Cells with the AFM
 

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Contents

Contents
35
Force Spectroscopy
65
DynamicMode AFM in Liquid
87
Fundamentals ofAFM Cantilever Dynamics in Liquid
121
Contents
126
SingleMolecule Force Spectroscopy
157
HighSpeed AFM for Observing Dynamic Processes in Liquid
189
Integration ofAFM with Optical Microscopy Techniques
211
Biological Applications
231
Atomic Force
259
Contents
277
SingleMolecule Atomic Force Microscopy ofCellular Sensors
285
AFMBased SingleCell Force Spectroscopy
307
Nanosurgical Manipulation ofLiving Cells with the AFM
331
Index
355
Copyright

Contents
217

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About the author (2012)

Arturo M Baro has spent most of his career at the Universidad Autonoma of Madrid and has been working in the fi eld of Surface Physics and Nanoscience. In 1983, he spent one year at the IBM Research Lab in Zurich where he worked with Professors Rohrer and Binnig, who
discovered STM. He is the author of 160 publications with a citation index h = 38. In 1985, he founded the company NANOTEC ELECTRONICA, S.L., which is dedicated to the fabrication and sale of AFM machines. He has been honored with the research prizes from the Humboldt
Foundation.

Ronald G. Reifenberger has been on the faculty at Purdue University, W. Lafayette, USA since 1978. Following his PhD in physics from the University of Chicago, he was a post-doctoral fellow at the University of Toronto, Canada. His nanophysics laboratory at Purdue uses
innovative experimental techniques to examine nanoscale properties of matter. His research focus since 1985 has been primarily scanning probe microscopy. Reifenberger is currently the director of the Kevin G. Hall Nanometrology Laboratory in the Birck Nanotechnology Center
at Purdue.

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