Atomic Force Microscopy in Liquid: Biological ApplicationsArturo M. Baró, Ronald G. Reifenberger About 40 % of current atomic force microscopy (AFM) research is performed in liquids, making liquid-based AFM a rapidly growing and important tool for the study of biological materials. This book focuses on the underlying principles and experimental aspects of AFM under liquid, with an easy-to-follow organization intended for new AFM scientists. The book also serves as an up-to-date review of new AFM techniques developed especially for biological samples. Aimed at physicists, materials scientists, biologists, analytical chemists, and medicinal chemists. An ideal reference book for libraries. From the contents: Part I: General Atomic Force Microscopy * AFM: Basic Concepts * Carbon Nanotube Tips in Atomic Force Microscopy with * Applications to Imaging in Liquid * Force Spectroscopy * Atomic Force Microscopy in Liquid * Fundamentals of AFM Cantilever Dynamics in Liquid * Environments * Single-Molecule Force Spectroscopy * High-Speed AFM for Observing Dynamic Processes in Liquid * Integration of AFM with Optical Microscopy Techniques Part II: Biological Applications * DNA and Protein-DNA Complexes * Single-Molecule Force Microscopy of Cellular Sensors * AFM-Based Single-Cell Force Spectroscopy * Nano-Surgical Manipulation of Living Cells with the AFM |
Contents
2 | 30 |
Carbon Nanotube Tips in Atomic Force Microscopy with Applications | 35 |
4 | 57 |
Force Spectroscopy | 65 |
DynamicMode AFM in Liquid | 87 |
Fundamentals of AFM Cantilever Dynamics in Liquid | 121 |
220 | 126 |
3 | 152 |
Integration of AFM with Optical Microscopy Techniques | 211 |
Biological Applications | 231 |
Segmental Mobility of DNA | 237 |
Intramolecular Triple Helices | 244 |
Chromatin Dynamics TimeLapse AFM | 251 |
Atomic Force | 259 |
SingleMolecule Atomic Force Microscopy of Cellular Sensors | 285 |
AFMBased SingleCell Force Spectroscopy | 307 |
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Common terms and phrases
acoustic adhesion forces AFM cantilever AFM imaging amplitude Appl applications atomic force microscopy beam Biol biological samples Biophys bond cantilever cantilever deflection cell surface Chem CNT AFM probes CNT AFM tips CNT tip cytoskeleton detection displacement dynamic-mode AFM EDL force eigenmode elastic electrostatic energy excitation experimental Figure fluid fluorescence fluorescence microscopy FM-AFM force curve Force pN force spectroscopy Fukuma function Hansma high-speed AFM hydrophobic Instrum interaction force interface Langmuir laser layer length Lett lipid bilayer liquid environments living cells magnetic mechanical method mica Microscopy in Liquid mode module molecular MWNT MWNT tips Nanotechnology optical peak phase photodiode Phys PID controller piezo piezoelectric properties protein quality factor resolution resonant frequency Sader scanning second eigenmode sensor signal silicon single single-molecule single-molecule experiments solvation spring constant stiffness streptavidin structure substrate SWNT technique thermal tip and sample titin unfolding vibration voltage z-scanner