Autism: Oxidative Stress, Inflammation, and Immune Abnormalities
In 2007, the Centers for Disease Control and Prevention issued an autism alarm, estimating that one in 150 children may be affected by autism spectrum disorder. Autism has been treated mainly with technical approaches: principally applied behavior analysis and psychopharmacology. The findings in this book implicate oxidative stress as a common feature in autism, and support the claim that oxidative stress and intracellular redox imbalance can be induced or triggered in autism by exposure to certain environmental agents. Such findings could point the way to new treatment approaches in autism.
Autism: Oxidative Stress, Inflammation, and Immune Abnormalities brings together a wealth of cutting-edge evidence that is already influencing how we treat this serious condition. It looks at the role of neuropathological abnormalities, genetics, and those factors common to oxidative stress such as inflammation, immune dysfunction, aberrant cellular signaling, and gene-environment interactions. Among dozens of research topics, this volume —
This book shows us that autism is not only developmental but also a chronic condition based on active pathophysiology, and that it is not only behavioral but also presents somatic and systemic features. The findings in these chapters support the theory that oxidative stress plays an important role in autism. They also point to the value of conducting in-depth mechanistic studies as a way to uncover new targets for therapeutic intervention in autism.
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Chapter 2 Evidence for Oxidative Damage in the Autistic Brain
Chapter 3 Oxidative Stress and Neurotrophin Signaling in Autism
Chapter 4 Genetics of Autism
Chapter 5 Phenotypic Expression of Autism Maternal Depression and the Monoamine OxidaseA Gene
Chapter 6 Paraoxonase 1 Status Environmental Exposures and Oxidative Stress in Autism Spectrum Disorders
A Molecular Mechanism for Heavy MetalInduced Neurotoxicity
Evidence from an Animal Model
Neural and Immune Network Interactions
Chapter 13 Possible Impact of Innate Immunity on Autism
What Is the Link?
Chapter 15 Possible Mechanism Involving Intestinal Oxytocin Oxidative Stress and Signaling Pathways in a Subset of Autism with Gut Symptoms
Their Role in Immune Alterations
Chapter 17 Autism Teratogenic Alleles HLADR4 and Immune Function
The Centrality of Active Pathophysiology and the Shift from Static to Chronic Dynamic Encephalopathy
The Need for a Biopsychosocial Perspective
Chapter 9 Neurotoxic Brainstem Impairment as Proposed Threshold Event in Autistic Regression
Chapter 10 Abnormalities in Membrane Lipids MembraneAssociated Proteins and Signal Transduction in Autism
Chapter 11 Mitochondrial Component of Calcium Signaling Abnormality in Autism