Autoantibodies in Neurological Diseases

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Angela Vincent, Gianvito Martino
Springer Science & Business Media, Sep 1, 2001 - Medical - 177 pages
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Immune-mediated neurological disorders present an increasing challenge to neu­ rologists. Recent advances have identified new antibodies, new effector mechanisms and new diagnostic tests; these have greatly enhanced our understanding of disease aetiology and opened up therapeutic opportunities, but a critical understanding of this fast -developing field is not easy to find. This volume was conceived following a very successful course on neuroimmu­ no logy in Bergamo in 2000, and was written mainly by clinicians who are active in the laboratory. It will help to keep practising neurologists and neuroimmuno­ logists abreast of the most recent developments, and to assess new information more critically. Angela Vincent and Gianvito Martino should be congratulated on master-min­ ding this timely and practical text. July 2001 J. Newsom-Davis Professor Emeritus University of Oxford Table of Contents Introduction -Approaches to Understanding Immune-Mediated Neurological Disorders: Measuring and Evaluating Autoantibodies to Neuronal Antigens G. MARTINO, A. VINCENT ..••.•...•...•..••...•.••..•....••.••.....
 

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Contents

New Antibodies to Neuronal and Muscle Antigens
15
Pregnancy and Myasthenia Gravis
28
Immunological Mechanisms in the LambertEaton Myasthenic Syndrome
40
Immunotherapy of Myasthenia Gravis
52
Ontogeny of Skeletal Muscle Cells
63
Idiopathic Inflammatory Myopathies Immunological Aspects
76
Immunological Mechanisms of Paraneoplastic Nervous System Diseases
93
Clinical Presentation and Mechanisms of ImmuneMediated Cerebellar Ataxia
104
StiffMan Syndrome Pathogenetic Nosological and Therapeutic Considerations
124
Paraneoplastic Neuropathies a Neuropathological Overview
136
OpsoclonusMyoclonus Syndrome in Childhood
144
Epilepsy and Autoantibodies
152
Primary and Secondary Vasculitis of the Central Nervous System
162
Subject Index
175
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Page 13 - Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J.
Page 14 - Autoantibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 2001; 7:365-8.

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