Autoantibodies in Neurological Diseases
Angela Vincent, Gianvito Martino
Springer Science & Business Media, Sep 1, 2001 - Medical - 177 pages
Immune-mediated neurological disorders present an increasing challenge to neu rologists. Recent advances have identified new antibodies, new effector mechanisms and new diagnostic tests; these have greatly enhanced our understanding of disease aetiology and opened up therapeutic opportunities, but a critical understanding of this fast -developing field is not easy to find. This volume was conceived following a very successful course on neuroimmu no logy in Bergamo in 2000, and was written mainly by clinicians who are active in the laboratory. It will help to keep practising neurologists and neuroimmuno logists abreast of the most recent developments, and to assess new information more critically. Angela Vincent and Gianvito Martino should be congratulated on master-min ding this timely and practical text. July 2001 J. Newsom-Davis Professor Emeritus University of Oxford Table of Contents Introduction -Approaches to Understanding Immune-Mediated Neurological Disorders: Measuring and Evaluating Autoantibodies to Neuronal Antigens G. MARTINO, A. VINCENT ..••.•...•...•..••...•.••..•....••.••.....
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Acad Sci acetylcholine receptor AChR acid activity Ann Neurol anti anti-AChR anti-Hu antibodies anti-Yo antibodies antigens associated autoantibodies autoimmune diseases azathioprine binding biopsy brain calcium channels cancer carcinoma cerebellar ataxia Clin clinical corticosteroids cytokines cytoplasm cytotoxic Dalmau detected disorders drugs EAMG effect encephalitis encephalomyelitis endothelial epilepsy epitopes expression fetal gene glutamic Graus F Hu-Ab human immune response Immunol immunological immunosuppressive inclusion body myositis induced infiltrates inflammatory myopathies inhibit intravenous immunoglobulin involvement Lambert-Eaton myasthenic syndrome LEMS lymphocytes mechanisms membrane MHC class mice molecules muscle fibres myasthenia gravis Myf5 myoblasts myogenesis myogenic nerve neuroblastoma Neuroimmunol Neurol Neurosurg Psychiatry neurological neuromuscular neurons neuropathy Neurosci opsoclonus opsoclonus-myoclonus paraneoplastic cerebellar degeneration pathogenesis peptide peripheral plasma exchange polymyositis Posner JB pregnancy protein Purkinje cells Rasmussen's encephalitis recombinant role satellite cells sensory serum somites specific stiff-man syndrome studies subacute subunit suggesting symptoms therapy tissue treatment tumour vasculitis VGCCs VGKC vitro
Page 13 - Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain. Am. J.