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Animal Models and Immunointervention
Transgenic mice carrying the rearranged T cell receptor of
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80 Autoimmunity Acad activity amino acid analysis anti-DNA antibodies anti-dsDNA antigen autoantibodies autoantigens autoimmune diseases autoreactive B-cell BALB/c binding CD4+ CD8+ cDNA CDR3 cell clones cell receptor cell repertoire Clin clonal competitor peptides deletion diabetes EBNA encoded epitopes expression fusion proteins gene segments germline heat shock protein heavy chain histone hsps human idiotype immune immunoglobulin Immunol induced infection insulitis Isenberg islet levels littermate lymphocytes lymphoma mechanisms MHC class molecular molecules Moncef Zouali monoclonal antibodies MRL/lpr murine Natl NOD mice normal overexpression pathogenic patients with RA peptides peripheral Proc react reactivity regulatory residues response Rheum rheumatoid arthritis role selection sequence sera serum shown SLE patients somatic mutations specific strains studies superantigens synovial fluid synthetic peptides systemic lupus erythematosus thymus tissue tolerance transcription transgenic transgenic mice ubiquitin variable region VH gene vitro vivo