Autonomic Dysfunction After Spinal Cord Injury

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Lynne C. Weaver, Canio Polosa
Gulf Professional Publishing, Oct 11, 2005 - Medical - 472 pages
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Autonomic dysfunction is a major and poorly understood consequence of spinal cord injury. It is a cause of very serious disability and requires much more research. It should be a focus of treatment strategies. This book will be of interest to anyone involved in research and treatment of spinal cord injury since it helps to explain the tremendously negative impact on the body caused by cord injury that is not as obvious as paralysis and loss of sensation. It contains a compilation of what is known about bladder, cardiovascular, bowel and sexual dysfunction after spinal cord injury, as it relates to the changes within the autonomic nervous system control of these functions.

The book begins with a description of the time course of autonomic dysfunctions and their ramifications from the first hours after a spinal cord injury to the more stable chronic states. The next section contains three chapters that address anatomical findings that may provide some of the foundation for autonomic dysfunctions in many of the systems. The system-specific chapters then follow in four sections. Each section begins with a chapter or two defining the clinical problems experienced by people with cord injury. The following chapters present research, basic and clinical, that address the autonomic dysfunctions.
 

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Contents

Autonomic dysfunction in spinal cord injury clinical presentation of symptoms and signs
1
Section I Anatomical Changes Mediating Autonomic Dysfunction After Cord Injury
9
Effects of spinal cord injury on synaptic inputs to sympathetic preganglionic neurons
11
Their identification and roles after spinal cord injury
27
Which pathways must be spared in the injured human spinal cord to retain cardiovascular control?
39
Section II Urinary Bladder Dysfunction
49
what are the problems?
51
Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury
59
central mechanisms and strategies for prevention
245
Segmental organization of spinal reflexes mediating autonomic dysreflexia after spinal cord injury
265
Spinal cord injury alters cardiac electrophysiology and increases the susceptibility to ventricular arrhythmias
275
Adaptations of peripheral vasoconstrictor pathways after spinal cord injury
289
Genetic approaches to autonomic dysreflexia
299
Section IV Bowel Dysfunction
315
Gastrointestinal symptoms related to autonomic dysfunction following spinal cord injury
317
Colorectal motility and defecation after spinal cord injury in humans
335

How good things might go bad
85
Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury
97
Effect of injury severity on lower urinary tract function after experimental spinal cord injury
117
Role of the urothelium in urinary bladder dysfunction following spinal cord injury
135
can we use it to advantage to reestablish effective bladder voiding and continence?
147
successes and failures
163
Novel repair strategies to restore bladder function following cauda equinaconus medullaris injuries
195
measures of functional loss and partial preservation
205
Section III Cardiovascular Dysfunction
221
an overview
223
Orthostatic hypotension and paroxysmal hypertension in humans with high spinal cord injury
231
Mechanisms controlling normal defecation and the potential effects of spinal cord injury
345
defecatory function and development of spasticity in pelvic floor musculature
359
Upper and lower gastrointestinal motor and sensory dysfunction after human spinal cord injury
373
Section V Sexual Dysfunction
385
Problems of sexual function after spinal cord injury
387
effects of chronic spinal lesions
401
effects of chronic spinal cord injury
415
Male fertility and sexual function after spinal cord injury
427
Female sexual function after spinal cord injury
441
Subject Index
449
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