Autonomic Dysfunction After Spinal Cord Injury
Lynne C. Weaver, Canio Polosa
Elsevier, Oct 11, 2005 - Medical - 472 pages
Autonomic dysfunction is a major and poorly understood consequence of spinal cord injury. It is a cause of very serious disability and requires much more research. It should be a focus of treatment strategies. This book will be of interest to anyone involved in research and treatment of spinal cord injury since it helps to explain the tremendously negative impact on the body caused by cord injury that is not as obvious as paralysis and loss of sensation. It contains a compilation of what is known about bladder, cardiovascular, bowel and sexual dysfunction after spinal cord injury, as it relates to the changes within the autonomic nervous system control of these functions.
The book begins with a description of the time course of autonomic dysfunctions and their ramifications from the first hours after a spinal cord injury to the more stable chronic states. The next section contains three chapters that address anatomical findings that may provide some of the foundation for autonomic dysfunctions in many of the systems. The system-specific chapters then follow in four sections. Each section begins with a chapter or two defining the clinical problems experienced by people with cord injury. The following chapters present research, basic and clinical, that address the autonomic dysfunctions.
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Which pathways must be spared in the injured human spinal cord to retain cardiovascular control?
Section II Urinary Bladder Dysfunction
what are the problems?
Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury
central mechanisms and strategies for prevention
Segmental organization of spinal reflexes mediating autonomic dysreflexia after spinal cord injury
Spinal cord injury alters cardiac electrophysiology and increases the susceptibility to ventricular arrhythmias
Adaptations of peripheral vasoconstrictor pathways after spinal cord injury
Genetic approaches to autonomic dysreflexia
Section IV Bowel Dysfunction
Gastrointestinal symptoms related to autonomic dysfunction following spinal cord injury
Colorectal motility and defecation after spinal cord injury in humans
How good things might go bad
Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury
Effect of injury severity on lower urinary tract function after experimental spinal cord injury
Role of the urothelium in urinary bladder dysfunction following spinal cord injury
can we use it to advantage to reestablish effective bladder voiding and continence?
successes and failures
Novel repair strategies to restore bladder function following cauda equinaconus medullaris injuries
measures of functional loss and partial preservation
Section III Cardiovascular Dysfunction
Orthostatic hypotension and paroxysmal hypertension in humans with high spinal cord injury
Mechanisms controlling normal defecation and the potential effects of spinal cord injury
defecatory function and development of spasticity in pelvic floor musculature
Upper and lower gastrointestinal motor and sensory dysfunction after human spinal cord injury
Section V Sexual Dysfunction
Problems of sexual function after spinal cord injury
effects of chronic spinal lesions
effects of chronic spinal cord injury
Male fertility and sexual function after spinal cord injury
Female sexual function after spinal cord injury
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activity acute arterial autonomic dysreflexia axons bladder afferent blood pressure bowel Brain Res cardiac cardiovascular central cervical clinical colon Comp defecation detrusor distension dorsal horn dorsal root ganglia dysfunction dyssynergia effects ejaculation electrical stimulation excitatory external anal sphincter external urethral sphincter fibers following spinal cord Frankel ganglion Groat heart rate hyperreflexia hypotension incontinence increased inhibition inhibitory innervation input intact interneurons Krassioukov lesions lower urinary tract lumbar lumbosacral male Mathias mechanisms mice micturition micturition reflex motoneurons motor nerve growth factor nervous system neurogenic Neurosci nitric oxide normal nucleus Paraplegia parasympathetic patients pelvic nerve penile Physiol primary afferent pseudorabies pudendal nerve receptor rectal rectum reflex pathways response segments sensory sexual function smooth muscle somatic sperm spinal cord injury spinal cord transection spinal sympathetic interneurons sprouting studies supraspinal sympathetic preganglionic neurons synaptic thoracic tion urethral sphincter urinary bladder Urol visceral Vizzard voiding Weaver Yoshimura