Autophagy in Health and Disease

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Roberta A. Gottlieb
Academic Press, Oct 16, 2012 - Medical - 227 pages
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Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information.
  • Discusses current understanding of the roles of autophagy in health and disease
  • Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes
  • Features an accompanying website with figures and tables
 

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Contents

Chapter 2 Molecular Machinery and Genetics of the Autophagy Pathway
11
Section II ORGAN SYSTEMS
31
Chapter 4 Autophagy in the Immune System
41
Chapter 5 Autophagy in the Gastrointestinal Tract
57
Chapter 6 Autophagy in the Homeostasis of Pancreatic βCells
89
Section III DISEASES AND PROCESSES
101
Chapter 8 Autophagy in Diabetes and the Metabolic Syndrome
117
An Endogenous Survival Mechanism and Cardioprotective Response to Ischemic Stress
141
Section IV Diagnosis and Therapeutics
159
Chapter 11 Measuring Autophagy in Vivo
181
Chapter 12 Aging Nutrition and Lifestyle
191
Sea of Knowledge
219
Index
221
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About the author (2012)

Dr. Gottlieb has been conducting NIH-funded cardiovascular research for the past 20 years. She has prior experience with The Scripps Research Institute (TSRI); SDSU where she became the first Director of the Donald P. Shiley BioScience Center, and currently as the Director of Molecular Cardiobiology at Cedars-Sinai Heart Institute.

The work in her lab has led to the discovery of the cardioprotective agents and the elucidation of their novel mechanism of action. Her expertise in cardioprotection and autophagy is recognized on a national and international level.

Dr. Gottlieb is also an entrepreneur, having started a biotechnology company called Radical Therapeutix, to develop drugs to mitigate the damage to the heart during myocardial infarction. Dr. Gottlieb received her B.S. and M.D. degrees from Johns Hopkins University.

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