Autophagy in Immunity and Infection: A Novel Immune Effector
John Wiley & Sons, Aug 21, 2006 - Science - 286 pages
This first book to cover this new topic at the interface of cell biology, immunology and infection biology offers a unique insight as to how the innate and possibly the adaptive immune system are shaped by cellular mechanisms. Following a comprehensive introduction to autophagy, the work features cellular mechanisms and medical implications, structured according to all major pathogens, while also covering emerging infectious diseases, such as tuberculosis. Edited by one of the authors of a groundbreaking paper on this topic.
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Acad Sci USA activity aggregates amino acid antigen apoptosis Atg1 Atg5 Atg7 Atg8 autophagic pathway autophagosomes autophagy autophagy genes bacteria bacterium beclin binding Biochem Biol Chem burnetii cancer caspase Cell Biol cellular Codogno compartments complex components Coxiella cytoplasm cytosolic D.J. Klionsky decreased disease effector endocytic function fusion GcAVs GFP–LC3 hepatocytes host cell IcsB IFN-c induce autophagy induction of autophagy Infect Immun inhibit inhibitor intracellular kinase late endosomes Legionella Levine liver lysosomal macroautophagy macrophages mammalian cells markers mechanism MHC class MHC class II mice Microbiol Mizushima molecular monocytogenes morphological mTOR mutant Natl Acad Sci neurons nutrient Ohsumi organelles pathogens phagosome PI3K post-infection Proc Natl Acad programmed cell death proteasome protein degradation rapamycin receptor regulation replication response role of autophagy Seglen sequestering Shigella signaling starvation studies survival target tein tion tophagy TORC1 vacuoles vesicles viral virus wild-type wortmannin yeast Yoshimori