Autosomal dominant polycystic kidney disease
Recent years have witnessed an explosion of knowledge on autosomal dominant polycystic kidney disease (ADPKD), one of the most common of all genetic diseases. The major ADPKD gene, PKD1, has now been identified and progress is being made towards identifying the PKD2 gene.
With contributions by leading researchers in the field, this volume stems from a seminar held in Vimercate, Italy, designed to discuss and evaluate the latest advances. The contributions update knowledge regarding various aspects of ADPKD, including molecular genetics, renal cystogenetic mechanisms and clinical considerations. They also present interesting epidemiological data and discuss ethical problems and issues relating to genetic counselling. In addition, an extensive section containing poster presentations provides the reader with an excellent overview of current directions in research on ADPKD.
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Pathogenesis of Renal Cysts in Dominantly Inherited Polycystic Kidney Disease
The Patient with ADPKD on Maintenance Hemodialysis
New Insights and Unanswered
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ADPKD patients adult polycystic kidney affected arterial pressure autosomal dominant polycystic Basel bilateral nephrectomy bile ducts blood pressure Breuning MH chromosome 16 Clin clinical collagen Conte F Contrib Nephrol correlation cyst fluid diagnosis dialysis dominant polycystic kidney end-stage renal ESRD ESRF family history females follow-up Gabow genetic Genomics growth factor hematuria hemodialysis hemorrhage hepatic cysts hypertension infection intracranial aneurysms Karger kidney disease ADPKD Kidney Int Kimberling WJ locus males markers mean age Milani S eds mutations Nephrology nephropathies non-PKDl normal normotensive onset of ESRD pairs patients with ADPKD phenotypic PKD1 PKD1 gene PKD2 plasma polycystic disease polycystic kidney disease Polycystic liver disease population prevalence progression rate protein Reeders ST renal cysts renal disease renal failure renal function renal replacement therapy renal transplantation rupture Serbelloni serum creatinine Sessa significant Soc Nephrol survival Table tubule twins