Avian Influenza

Front Cover
Hans-Dieter Klenk, Mikhail N. Matrosovich, Jürgen Stech
Karger Medical and Scientific Publishers, Jan 1, 2008 - Medical - 292 pages
Because of its high impact on both animal and human health, avian influenza has become a matter of increasing public concern and growing scientific interest within the last decade. This volume gives an overview of the most important results of these research efforts and provides information about the ecology and epidemiology of avian influenza with particular emphasis on recent H5N1 outbreaks in China, Siberia and Europe. Several articles deal with new vaccination strategies, the use of antivirals and other control measures to combat outbreaks of avian influenza. Further chapters illustrate that molecular biology, culminating in the generation of influenza viruses by recombinant DNA technology, was instrumental in unravelling the roles of the viral hemagglutinin and polymerase as well as cellular signalling pathways and innate immunity in pathogenesis and interspecies transmission. Finally, the threat of a pandemic originating from avian influenza viruses is illustrated by the example of the Spanish influenza of 1918.This comprehensive publication on avian influenza viruses and their relevance for human influenza will be of great value to all influenza virologists, molecular biologists, public health scientists, veterinary virologists, ecologists, and scientists engaged in drug design and vaccine development.
 

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Contents

Epidemiology of Avian Influenza
1
H5N1 in Asia
11
Epidemiology and Control of H5N1 Avian Influenza in China
27
Avian Influenza in Northern Eurasia
41
Avian Influenza in Italy 19972006
59
Avian Influenza Outbreaks in Germany Development of New Avian Vaccines
71
The Role of Pigs in Interspecies Transmission
88
History of Research on Avian Influenza
101
Transcription and Replication
168
A Determinant of Host Range and Pathogenicity
187
Recent Insights from New Mouse Models
195
Influenza Viruses and Intracellular Signal Transduction Cascades
210
Cytokines in the Pathogenesis of Highly Virulent Influenza Viruses in Humans
225
Antivirals and Resistance
252
Lessons from the Past Raise Questions for the Future
272
Author Index
287

Reverse Genetics of Influenza Viruses Applications in Research and Vaccine Design
118
Receptor Specificity of Influenza Viruses and Its Alteration during Interspecies Transmission
134
Cleavage Activation of the Influenza Virus Hemagglutinin and Its Role in Pathogenesis
156

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