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alignment alternative splicing amino acid analysis annotations applications approach biclusters Bioinformatics biological biomedical cancer cell classification clustering algorithm combination complex DABSS database dataset defined denote detect developed dihedral angle distance distribution disulfide bonds domain evaluation example experiments extracted feature Figure fractal function gene expression gene expression data Gene Ontology genetic genome geometric hashing graph identify IEEE Informatics input integration interaction ISXL length match matrix measure Medical method microarray Molecular molecules mutations node nucleotide ontology optimal parameters patterns performance prediction problem proposed protein pairs protein structure protein-protein interaction query residues retrieval samples score Section segmentation selected semantic terms sequence similarity simulated SNPs spaced seeds specific step string substring SWISS-PROT Table Taiwan TATA Box techniques threshold tion tree tumor values variables vector VNTR voxel Web services