Bacteria, Complement, and the Phagocytic Cell
Felipe C. Cabello, Carla Pruzzo
Springer-Verlag, Jan 1, 1988 - Medical - 372 pages
Phagocytic cells and complement are probably the most important components of host defense against bacteria which, after overcoming the mucosal and epithelial barriers, multiply in the subepithelial tissue and may threaten to disseminate and invade the blood stream and different organs. Questions concerning the factors which regulate the interactions of the bacterial cell with host defenses are a challenge to research and lead to practical applications for the prevention, treatment and diagnosis of infectious diseases. The questions of expression and regulation of virulence related bacterial genes and gene products, the specific mechanisms of defence reactions by complement and phagocytic cells, their mutual interactions with bacteria and especially bacterial surfaces are focused. Considerations on how to translate this knowledge into the management of infectious diseases are also included.
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The murein sacculus the bacterial exoskeletonstructure
Chemical nature and cellular location of adhesins
Genetics of 0 antigen polysaccharide biosynthesis
14 other sections not shown
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acid adhesin aeruginosa alternative complement pathway alternative pathway amino anti-J5 antigen ascites aureus bacteria bacterial surface bactericidal bactericidal activity Berlin Heidelberg 1988 binding blood capsular polysaccharide capsule cell surface chromosomal clearance cloned ColW complement activation complement-mediated components determinants domains dysenteriae enzyme Escherichia coli F.C. Cabello factor fibrinogen fimbriae Fischetti function genetic gram-negative group A streptococci H.24 Bacteria homologous host defense human serum Immunol incubated Infect Immun inhibit interaction intracellular isolated Jann killing lectins leukocytes lipid lipopolysaccharide macrophages mannose mechanism mediated mice Microbiol molecular molecules monoclonal antibodies monocytes mouse murein mutants non-secretors opsonic opsonins organisms outer membrane PapG pathogens peptide peritoneal Phagocytic Cell Edited phagocytosis phagosome plasmid PMNs pneumophila polysaccharide protein Pruzzo receptors region role Salmonella typhimurium secretor sequence serogroup serotype serum resistance Shigella shown side chains specific strains structure studies subunits Table typhi vaccine virulence vitro Waltonen