Bacteria, complement and the phagocytic cell
Springer-Verlag, 1988 - Health & Fitness - 372 pages
Phagocytic cells and complement are probably the most important components of host defense against bacteria which, after overcoming the mucosal and epithelial barriers, multiply in the subepithelial tissue and may threaten to disseminate and invade the blood stream and different organs. Questions concerning the factors which regulate the interactions of the bacterial cell with host defenses are a challenge to research and lead to practical applications for the prevention, treatment and diagnosis of infectious diseases. The questions of expression and regulation of virulence related bacterial genes and gene products, the specific mechanisms of defence reactions by complement and phagocytic cells, their mutual interactions with bacteria and especially bacterial surfaces are focused. Considerations on how to translate this knowledge into the management of infectious diseases are also included.
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The murein sacculus the bacterial exoskeletonstructure
Chemical nature and cellular location of adhesins
Genetics of 0 antigen polysaccharide biosynthesis
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acid adhesin aeruginosa alternative complement pathway alternative pathway amino anti-J5 antigen ascites aureus bacteria bacterial surface bactericidal bactericidal activity binding blood Cabello capsular polysaccharide capsule cell surface chromosomal cloned ColV complement activation complement-mediated components determinants domains dvsenteriae enzyme Escherichia coli factor fibrinogen fimbriae function genetic gram-negative group A streptococci H24 Baeteria Haemophilus influenzae homologous host defense human serum Immunol incubated Infect Immun inhibit interaction intracellular isolated Jann killing lectins leukocytes lipid lipopolysaccharide macrophages Makela mannose mechanism mediated mice Microbiol molecular molecules monoclonal antibodies monocytes mouse murein mutants non-secretors O-antigen opsonic opsonins organisms outer membrane pathogens peptide peritoneal phagocytes phagocytosis Phagoeytie Cell Edited phagosome plasmid PMNs pneumophila polysaccharide protein Pruzzo Pseudomonas aeruginosa receptors region role Salmonella Salmonella tvphimurium secretors sequence serogroup serum resistance Shigella shown side chains specific strains structure studies subunits Table vaccine Valtonen virulence vitro