Bacterial Protein Toxins

Front Cover
K. Aktories, I. Just
Springer Science & Business Media, Apr 26, 2000 - Medical - 700 pages
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In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
 

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Contents

CHAPTER
1
Retrograde Vesicular Transport
7
References
14
CHAPTER 2
21
E Eukaryotic MonoADPRibosyltransferases
35
CHAPTER 3
45
The DiphtheriaToxin Receptor
51
References
61
F Conclusions
351
CHAPTER 16
361
E StructureFunction Relationships of CNF1 and the Family
373
G Conclusions
379
CHAPTER 17
385
StructureFunction Analyses of Stx Family Members
392
G Summary
399
CHAPTER 18
407

CHAPTER 4
67
Intoxication of Eukaryotic Cells
76
References
82
CHAPTER 5
91
E Clinical Evaluation of DAB486IL2 and DAB389IL2
98
References
104
B ThreeDimensional Structures of Holotoxins
110
F Enzymatic Mechanism
117
G The LTII Family
120
CHAPTER 7
133
Summary
152
CHAPTER 8
167
Membrane Translocation of PTX
170
E The Enzyme Mechanism of SI Catalyzed ADPRibosylation
176
H Conclusions
182
B Molecular Aspects of PT Activity on G Proteins
189
Functional Consequences of PT Activity
195
CHAPTER 10
207
Genetics of C3 and C3Like Exoenzymes
209
F Application of C3Like Exoenzymes as Tools
218
References
225
CHAPTER 11
235
ExoS is a Bifunctional Cytotoxin
244
K Functional and Sequence Relationship Between ExoS and
247
CHAPTER 12
253
Difficile Toxin
266
CHAPTER 13
275
CHAPTER 14
307
Molecular Mode of Action
315
E Concluding Remarks
327
CHAPTER 15
333
Mechanism of Action
341
Structure of Clostridial Neurotoxins
412
E Toxicodynamics of Clostridial Neurotoxins
422
References
431
CHAPTER 19
445
Cellular Uptake and Internalization
456
E Intracellular Actions
462
CHAPTER 20
473
Possible Roles for AC Toxin in Pathogenesis
480
CHAPTER 21
489
Regulation of vacA Gene Expression
495
G Clinical Relevance of the Vacuolating Cytotoxin
502
CHAPTER 22
509
E Biological Effects
517
H Medical Relevance of a Toxin
523
CHAPTER 23
529
Modulation of Eukaryotic Cell Metabolism
538
F Role in Disease
544
CHAPTER 24
557
Concluding Remarks
573
Receptor for STa
580
E Concluding Remarks
588
CHAPTER 26
595
Other Superantigens or Pseudosuperantigens of GramPositive
607
E The M Arthritidi s Superantigen
610
CHAPTER 27
619
Biosynthesis of LPS
632
F Strategies for the Treatment of GramNegative Infections
644
G Final Remarks
651
CHAPTER 28
669
Perspectives
683
Subject Index
691
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Aktories, Institut fur Pharmakologie und Toxikologie, Albert-Ludwigs-Universitat Freiburg, Germany.

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