Bacterial Toxins: Tools in Cell Biology & Pharmacology
John Wiley & Sons, Sep 26, 2008 - Science - 334 pages
This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance.
A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.
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actin activity adenylate cyclase ADP-ribosylation ADP-ribosylation factor ADP-ribosyltransferase Ahnert-Hilger Aktories alpha-toxin amino acid antibodies assay bacterial Bhakdi binding Biochem biological BoNT/A BoNTs botulinum C2 toxin botulinum neurotoxin buffer C-terminal C3 exoenzyme Ca2+ Cell Biol cell line cellular centrifugation Chem cholera toxin cleavage cleaved clostridial neurotoxins Clostridium botulinum Clostridium difficile Clostridium difficile toxin CNTs coli component concentration containing culture cytoskeleton cytosol diphtheria toxin domain effects enzymatic enzyme etal exocytosis exoenzyme F-actin factor fusion protein G proteins gene glucosylation GTP-binding protein GTPases guanine Immun incubated Infect inhibition insulin insulin-secreting intracellular iota toxin light chain membrane microiniection molecular molecule Montecucco mutant neurons neurotoxins nucleotide Ohishi peptide permeabilization pertussis toxin pore-forming Purification receptor recombinant release residue Rho proteins ribosylation sample SDS-PAGE Sigma solution structure substrate subunit supernatant synaptic vesicle synaptosomes syntaxin tetanus toxin TeTx tion ToxA transferase translocation trypsin VAMP