Springer US, May 31, 1993 - Medical - 413 pages
Bacterial plasmids originating in a wide range of genera are being studied from a variety of perspectives in hundreds of laboratories around the globe. These elements are well known for carrying "special" genes that confer important survival properties, frequently neces sary under atypical conditions. Classic examples of plasmid-borne genes are those provid ing bacterial resistance to toxic substances such as antibiotics, metal ions, and bacte riophage. Often included are those determining bacteriocins, which may give the bacterium an advantage in a highly competitive environment. Genes offering metabolic alternatives to the cell under nutritionally stressed conditions are also commonly found on plasmids, as are determinants important to colonization and pathogenesis. It is likely that in many, if not most, cases plasmids and their passenger determinants represent DNA acquired recently by their bacterial hosts, and it is the characteristic mobility of these elements that enables their efficient establishment in new bacterial cells by the process known as conjugation. Whereas many plasmids are fully capable of promoting their own conjugal transfer, others move only with help from coresident elements. The ability of a plasmid to establish itself in a variety of different species is com mon, and recent studies have shown that transfer can in some cases occur from bacterial cells to eukaryotes such as yeast.
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A Historical Perspective
Conjugational DNA Metabolism
Genetic Organization of TransferRelated Determinants on the
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Acad acid activity Agrobacterium tumefaciens analysis antibiotic resistance bacterial conjugation Bacteriol bacteriophage Bacteroides binding Biol broad host range catabolism characterization chromosome Clewell cloned cointegrates conjugal transfer conjugation system conjugative plasmids containing copy number deletion determined DNA sequence DNA transfer donor elements encoded Escherichia coli expression F plasmid faecalis Figure filamentous finP frequency functions gene products Genet gram-negative helicase Hfr strains homology IncP plasmids initiation insertion integration interaction involved isolated iterons located mapping mating mechanism Microbiol mobilization molecular molecules mutants Natl nick nucleotide nucleotide sequence octopine operon opine oriT region Paranchych phenotype pheromone pili pilin pilus plasmid DNA plasmid transfer primase Proc promoter protein Pseudomonas aeruginosa recipient cell recombination regulation replication replicon RNA phages sex factor single-stranded site-specific Skurray specific strand Streptococcus Streptomyces structure studies synthesis T-DNA Tra2 traJ Tral traM transcript transfer genes transfer origin transfer region transfer systems transposition transposon traY vitro Willetts