Bacterial Endotoxins: Lipopolysaccharides from Genes to Therapy

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Wiley, Aug 24, 1995 - Medical - 608 pages
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Progress in Clinical and Biological Research, Volume 392 Bacterial Endotoxins Lipopolysaccharides From Genes to Therapy Proceedings of the Third Conference of the International Endotoxin Society, Held in Helsinki, Finland, August 15–18, 1994 Jack Levin, Carl R. Alving, Robert S. Munford, and Heinz Redl, Editors In the past two decades, the scope of research in the field of bacterial endotoxins has expanded dramatically. Bacterial Endotoxins: Lipopolysaccharides From Genes to Therapy contains the most recent basic and clinical work of researchers studying lipopolysaccharides (LPS), including everything from recent findings on the molecular genetics and biosynthesis of LPS, to various aspects of endotoxin tolerance. Assembling information from the work of renowned international researchers, the book is divided into ten well-organized sections, each of which includes papers representing the state of the art in LPS investigations. Specific topics covered in the text include:
  • the structure and biosynthesis of Rhizobium leguminosarum lipid A
  • conformation and fluidity of endotoxins as determinants of biological activity
  • modalities of endotoxin binding to CD14
  • rational computer-aided design of ligands that bind endotoxin
  • formation of a TNF synthesis inhibitor in endotoxin tolerance
  • monophosphoryl lipid A as a prophylactic for sepsis and septic shock
Bacterial Endotoxins: Lipopolysaccharides From Genes to Therapy provides a clear reflection of the vitality of the bacterial endotoxin macromolecule and its biological effects. This book will appeal to laboratory and clinical medical microbiologists, immunologists studying bacterial endotoxins, and internal medicine specialists who are treating inflammatory disease. The breadth of coverage will also make it a valuable resource for researchers within both the biotechnology and pharmaceutical fields.

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Contents

Increased Substitution of Phosphate Groups
13
MICROBIOLOGICAL
33
Function of Lipopolysaccharide in the Invasion of Neisseria
49
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About the author (1995)

Jack Levin is the Irving and Betty Brudnick Professor of Sociology and Criminology at Northeastern University. He has authored or coauthored a number of books, including Elementary Statistics in Social Research, The Functions of Prejudice, Gossip: The Inside Scoop, Hate Crimes: The Rising Tide of Bigotry and Bloodshed, and Overkill: Mass Murder and Serial Killing Exposed. Levin's work has appeared in professional journals, including Youth & Society, Criminology, The Gerontologist, and Sex Roles, as well as in the New York Times, the Boston Globe, the Dallas Morning News, the Chicago Tribune and USA Today. He has lectured on campuses around the country about serial murder, hate crimes, and domestic terrorism. A dedicated educator and social advocate, Jack Levin received Northeastern University's Excellence in Teaching Award and was honored by the Council for Advancement and Support of Education as its Professor of the Year in Massachusetts.

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