Bacterial plasmids; conjugation, colicinogeny and transmissible drug-resistance
This is a sound, scholarly, yet very readable book that organizes the pertinent material on a relatively popular topic in bacterial genetics. In a complicated area where articles are scattered throughout the literature, it should prove an excellent reference source for researchers in microbial genetics and general microbiology, as well as in certain aspects of clinical medicine and in nutrition. Drug-resistance factors are accessory chromosomes, independent of the bacterial chromosome proper, which are of increasing practical concern as they cause a large portion of the antibiotic resistance that is prevalent in medicine and in veterinary practice. Yet these factors are only part of a much larger class of accessory chromosomes known as &"plasmids&" which have played a prominent role in the development of bacterial genetics of molecular biology as a whole. Two other well-known classes are the sex factors, which enable bacteria to transfer their genes to recipients by conjugation, and the bacterial phages&-viruses that grow in bacteria. Despite the great differences in their overt properties, all plasmids exhibit strong fundamental similarities, and it is these general properties rather than their individual peculiarities which are emphasized here. The book first notes how plasmids were discovered. It then discusses the physical structure of their chromosomes, their manner of replication, how they act to bring about conjugation, and other processes they determine. Although the treatment is primarily biological, the book supplies references to laboratory techniques and to the implications of the subject for human and for animal medicine.
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The discovery of plasmids
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acridine antigenic appears attP autonomous plasmid Bact bacterial bacterial conjugation bacteriocins Biol catenanes cells chromo chromosomal chromosomal genes chromosomal recombinants chromosomal transfer cistrons clones closed circular co-transfer Col+ ColE2 ColIb-P9 colicin colicin factor conjugation cross-over culture defective Deletion mapping density determined donor ability drug-resistance duplex E.coli enterobacteria enzymes episome Escherichia coli Escherichia coli K12 excision F factor F phage figure Flac frequency function G. G. Meynell gene transfer genetic genome growth Hfr strain homology host I-like induced infection integration isolated known Lac+ linear lysogenic lysogenised mating membrane Microbiol molec molecular weight molecules monomers mutants non-transmissible normal occurs oligomers operon phage genome pilin pilus plasmid plasmid and chromosome plasmid DNA presumably prophage protein recA recipient region replication replicon repressed repressor resistance Salmonella typhimurium segregants selection sex factor sex pili specific strains carrying strand supercoils superinfection superinfection immunity synthesis tion transduction transmissible wild type