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The subunit toxins
Membranedamaging toxins primary event defined
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acid adenylate cyclase ADP-ribosylation animals anthrax antibodies antigen antitoxin bacterial toxins binding biological blood botulinum toxin cause cell membrane cereus chauvoei cholera toxin clostridial Clostridium perfringens coli colicin complex component culture filtrates cytolysins daltons diarrhoea diphtheria toxin disease effects endogenous pyrogen endotoxin enterotoxic enterotoxins enzymes exfoliatin exotoxin experimental extracellular factors fluid fragment gas gangrene Gram-negative granulocytes guinea pigs haemolysin haemolytic haemorrhagic histamine ileal immunity immunological important inactivation induced infection inhibition injection of endotoxin interaction intestinal intravenous isolated lesions lethal leucocidin leucocytes lipid liver mechanism mice microbial mode of action molecular weight molecule mucosa murine toxin muscle neurone neurotransmitter novyi observed oedema organisms pathogenicity perfringens a-toxin perfringens type pestis phospholipase produced protein synthesis purified rabbits rats receptors release response role septicum sheep shock similar specific spores staphylococcal stimulation strains streptococcal streptolysin-O structure studies sub-unit suggested susceptible cells synaptic tetanus toxin tissue toxic toxigenic toxoids vaccine virulence vitro vivo