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Toxins which act extracellularly
Toxins which act on or within membranes
Toxins which traverse cell membranes and kill cells
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acid adenylate cyclase ADP-ribosylation animals anthrax anthrax toxin antibody antigens antitoxin bacterial toxins binding biochemical biological blood botulinum toxin caused cell membrane Chapter cholera toxin clostridial Clostridium coli colleagues colon complex component culture filtrates cyclase activity cytolysins cytoplasm damage diarrhoea difficile toxin diphtheria toxin disease effects endogenous pyrogen endotoxin enterocytes enterotoxins enzyme evidence exfoliatin exotoxin experimental extracellular factor fluid secretion fragment gas gangrene guinea-pigs haemolytic haemorrhage histamine ileal ileum immunity important inactivation increase induced infection inhibition interaction intestine involved isolated lesions lethal leucocidin lipid liver mechanism mice mode of action molecular molecule mucosa murine toxin muscle novyi o-toxin observed oedema organisms pathogenicity perfringens type pertussis toxin phospholipase primary produced proteases protein synthesis purified rabbits receptors release response role septicum sheep shiga toxin specific staphylococcal stimulated strains streptolysin-O structure studies sub-unit suggested susceptible cells tetanus toxin tion tissue toxic toxigenic toxoid vaccine vesicles virulence vitro vivo