Bacteriophage: Genetics and Molecular Biology
Stephen Mc Grath, Douwe van Sinderen
Caister Academic Press, 2007 - Science - 343 pages
Bacteriophages (viruses that infect bacteria) are fascinating organisms that have played and continue to play a key role in bacterial genetics and molecular biology. Phage can confer key phenotypes on their host - for example, converting a non-pathogenic strain into a pathogen - and they play a key role in regulating bacterial populations in all sorts of environments. The phage-bacterium relationship varies enormously, from the simple predator-prey model to a complex, almost symbiotic relationship that promotes the survival and evolutionary success of both. While infection of bacteria used in the fermentation industry can be very problematic and result in financial losses, in other scenarios, phage infection of bacteria can be exploited for industrial and/or medical applications. Interest in phage and phage gene products as potential therapeutic agents is increasing rapidly and is likely to have a profound impact on the pharmaceutical industry and biotechnology in general over the coming years. One potential application is the use of phage to combat the growing menace of antibiotic-resistant infections. Written by eminent international researchers actively involved in the disparate areas of bacteriophage research, this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current, most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype, and much more. The book will be essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology, and pharmaceutical companies, as well as in the food industry.
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Bacteriophage Bioinformatics and Genomics
Bacteriophage in the Environment
Bacteriophages and Food Fermentations
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0A box Acad acid activity analysis antibiotics antibody Appl aureus Bacillus subtilis bacterial Bacteriol bacteriophage bacterium binding Biol Breitbart Brussow capsid cell wall characterization chromosome cyanophages cycle dairy detection dimers DNA replication domain dsDNA ecology effect encoded endolysin Environ Escherichia coli fermentation filamentous phage Fischetti functional gene genetic genome sequence holin host cell host range immune induced interactions isolated Klaenhammer Lactococcus lactis lambda lysin lysis lysogenic lytic cycle marine mechanisms membrane metagenomics mice microbial Microbiol Moineau molecular mutants Natl pathogens peptidoglycan phage DNA phage genome phage infection phage particles phage therapy plasmid polymerase Proc production prokaryotic promoter prophage prophage induction protein RBPs RecA receptor recombination region regulatory repressor resistance role Salas Salmonella Siphoviridae Slopek specific Spo0A strains Streptococcus Streptococcus thermophilus structure studies Sulakvelidze Suttle tail fibers temperate phages thermophilus titers toxin transcription treatment viral virion Virology virulence virus viruses vitro vivo Weber-Dabrowska Weinbauer