## Basic Biostatistics for Geneticists and Epidemiologists: A Practical ApproachAnyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures. This Book: - Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares.
- Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research.
- Is illustrated throughout with simple examples to clarify the statistical methodology.
- Explains Bayes’ theorem pictorially.
- Features exercises, with answers to alternate questions, enabling use as a course text.
Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics. |

### What people are saying - Write a review

We haven't found any reviews in the usual places.

### Contents

3 | |

2 POPULATIONS SAMPLES AND STUDY DESIGN | 19 |

3 DESCRIPTIVE STATISTICS | 45 |

4 THE LAWS OF PROBABILITY | 79 |

5 RANDOM VARIABLES AND DISTRIBUTIONS | 107 |

6 ESTIMATES AND CONFIDENCE LIMITS | 131 |

7 SIGNIFICANCE TESTS AND TESTS OF HYPOTHESES | 155 |

8 LIKELIHOOD RATIOS BAYESIAN METHODS AND MULTIPLE HYPOTHESES | 187 |

11 ANALYSIS OF VARIANCE AND LINEAR MODELS | 265 |

12 SOME SPECIALIZED TECHNIQUES | 293 |

13 GUIDES TO A CRITICAL EVALUATION OF PUBLISHED REPORTS | 321 |

EPILOGUE | 329 |

REVIEW PROBLEMS | 331 |

ANSWERS TO ODDNUMBERED PROBLEMS | 345 |

APPENDIX | 353 |

365 | |

### Other editions - View all

Basic Biostatistics for Geneticists and Epidemiologists: A Practical Approach Robert C. Elston,William Johnson No preview available - 2008 |

Basic Biostatistics for Geneticists and Epidemiologists: A Practical Approach Robert C. Elston,William Johnson No preview available - 2008 |

Basic Biostatistics for Geneticists and Epidemiologists: A Practical Approach Robert C. Elston,William Johnson No preview available - 2008 |

### Common terms and phrases

allele analysis of variance appropriate approximately assume average Bayes factor binomial distribution blood pressure calculate Chapter chi-square distribution cholesterol clinical trial completely randomized design compute confidence interval consider correlation coefficient covariance cumulative degrees of freedom denote determine disease drug equal event example experimental Figure frequency function genetic Geneticists and Epidemiologists hypothesis is true independent investigator likelihood ratio main effects maximum likelihood estimate mean square measure median method mg/dl multivariate null hypothesis number of degrees observed obtain occur outcomes p-value pair parameters particular patients percentile permutation persons possible predictor variables prior probabilities proportion random sample random variable randomly assigned regression analysis regression model research hypothesis residual response variable result sample mean serum cholesterol levels significance level standard deviation statistical test study units sum of squares Suppose survival t-distribution t-test total number treatment groups triglyceride triglyceride level true father two-sided test type I error values zero