# Basic Biostatistics for Geneticists and Epidemiologists: A Practical Approach

John Wiley & Sons, Nov 20, 2008 - Medical - 384 pages
Anyone who attempts to read genetics or epidemiology research literature needs to understand the essentials of biostatistics. This book, a revised new edition of the successful Essentials of Biostatistics has been written to provide such an understanding to those who have little or no statistical background and who need to keep abreast of new findings in this fast moving field. Unlike many other elementary books on biostatistics, the main focus of this book is to explain basic concepts needed to understand statistical procedures.

This Book:

• Surveys basic statistical methods used in the genetics and epidemiology literature, including maximum likelihood and least squares.
• Introduces methods, such as permutation testing and bootstrapping, that are becoming more widely used in both genetic and epidemiological research.
• Is illustrated throughout with simple examples to clarify the statistical methodology.
• Explains Bayes’ theorem pictorially.
• Features exercises, with answers to alternate questions, enabling use as a course text.

Written at an elementary mathematical level so that readers with high school mathematics will find the content accessible. Graduate students studying genetic epidemiology, researchers and practitioners from genetics, epidemiology, biology, medical research and statistics will find this an invaluable introduction to statistics.

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### Contents

 1 INTRODUCTION THE ROLE AND RELEVANCE OF STATISTICS GENETICS AND EPIDEMIOLOGY IN MEDICINE 3 2 POPULATIONS SAMPLES AND STUDY DESIGN 19 3 DESCRIPTIVE STATISTICS 45 4 THE LAWS OF PROBABILITY 79 5 RANDOM VARIABLES AND DISTRIBUTIONS 107 6 ESTIMATES AND CONFIDENCE LIMITS 131 7 SIGNIFICANCE TESTS AND TESTS OF HYPOTHESES 155 8 LIKELIHOOD RATIOS BAYESIAN METHODS AND MULTIPLE HYPOTHESES 187
 11 ANALYSIS OF VARIANCE AND LINEAR MODELS 265 12 SOME SPECIALIZED TECHNIQUES 293 13 GUIDES TO A CRITICAL EVALUATION OF PUBLISHED REPORTS 321 EPILOGUE 329 REVIEW PROBLEMS 331 ANSWERS TO ODDNUMBERED PROBLEMS 345 APPENDIX 353 INDEX 365

 9 THE MANY USES OF CHISQUARE 203 10 CORRELATION AND REGRESSION 233