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VERNONROBERTS B 1
Screening for AntiRheumatic Activity
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accumulation ratio acid agents analysis Anti-Rheumatic Drugs antibodies antigen Arthritis Rheum assay auranofin binding Biochem Capell cellular chloroquine chronic Clin Clinical Pharmacology clinical response concentrations Cs-A cyclooxygenase cytokines cytotoxicity D-penicillamine disease activity dosage dose enantiomers endothelial cells enzymes glucocorticoids gold compounds gold therapy human ibuprofen IL-la IL-lB immune Immunol increase induced inflammatory inhibition inhibitors interactions interleukin kinetics leukocytes leukotriene liver lymphocyte lysosomal macrophages mechanism of action mediators membrane metabolism metabolites methotrexate monocytes mononuclear phagocytes mRNA neutrophils non-steroidal anti-inflammatory drugs NSAIDs oral P-SH patients with rheumatoid pharmacokinetics Pharmacol placebo plasma platelets potential production prostaglandin protein Rainsford rats reactions receptors reduced release reported Rheumatic Diseases rheumatoid arthritis rheumatoid factor Rheumatol Rheumatology role SARDs SASP second line serum side effects sodium aurothiomalate stimulation studies sulphasalazine sulphoxidation superoxide Suppl synovial fluid synthesis therapeutic thiomalate tissue toxicity treatment of rheumatoid ulcer variability in response vascular vitro vivo