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Phenotypic assessment of basal behaviors in Chrnal mice
Phenotypic assessment of nicotinemediated behaviors in Chrna2 mice
Discussion and Conclusions
2 other sections not shown
1.25 mg/kg nicotine 18-Methoxycoronaridine a2 subunit a2 subunit-containing nAChRs a2-containing nAChRs a4p2 nAChR accelerating rotarod agonist antinociception Balestra baseline latencies behavioral tests beta binding sites Brain Res changes in motor channel Chrna2 mice Chrna2+1 Chrnal1 Chrnbl'1 difference dopaminergic pathway elevated-plus maze expressed extracellular Figure five trials form functional receptors formalin formalin test Glick h alpha habenula habenulointerpeduncular pathway habituated environment hindpaw hippocampus hot-plate hyperactivity interneurons interpeduncular nucleus IPN lesions Ishii Khiroug knockout mice late phase Marubio mediated mesocorticolimbic dopaminergic mesolimbic dopaminergic system mice show increased mice show nicotine-mediated Mice were injected modulate motor coordination motor learning mouse mRNA mutant nAChR subunit Nakauchi narrow beam traversal neuronal nicotinic acetylcholine Neurosci nicotine administration nicotine analgesia nicotine-mediated antinociception nicotinic acetylcholine receptor nicotinic receptors nociceptive novel environment oocytes open-field phenotypes presynaptic rats role sensitivity SHIRPA show nicotine-mediated analgesia show no changes studies suggests tail withdrawal assay thalamus Viable Wada wild-type