Bentley's Textbook of Pharmaceutics

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Elsevier Health Sciences, May 14, 2012 - Medical - 776 pages
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This adaptation of Bentley's Textbook of Pharmaceutics follows the same goals as those of the previous edition, albeit in a new look. The content of the old edition has been updated and expanded and several new chapters, viz. Complexations, Stability Testing as per ICH Guidelines, Parenteral Formulations, New Drug Delivery Systems and Pilot Plant Manufacturing, have been included, with an intention to make the book more informative for the modern pharmacists.

The book has six sections:

  • Section I deals with the physicochemical principles. Two new chapters: Complexations and ICH Guidelines for Stability Testing, have been added to make it more informative.
  • Section II conveys the information regarding pharmaceutical unit operations and processes.
  • Section III describes the area of pharmaceutical practice. Extensive recent updates have been included in many chapters of this section. Two new chapters: Parenteral Formulations and New Drug Delivery Systems, have been added.
  • Section IV contains radioactivity principles and applications.
  • Section V deals with microbiology and animal products.
  • Section VI contains the formulation and packaging aspects of pharmaceuticals. Pilot Plant Manufacturing concepts are added as a new chapter, which may be beneficial to readers to understand the art of designing of a plant from the pilot plant model.
 

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Contents

Conversion Between Times Gravity G and Centrifuge Rotor Speed RPM
Laboratory Equipment
Zonal Centrifugation
Supercentrifuge
LargeScale Equipments
Chapter 18
Factors Affecting the Rate of Filtration
Filter Media

Expression of Solubility According to Pharmacopoeia
Solutions of Solids in Liquids
The Determination of Solubility
Solubility Curves
Supersaturated Solutions
Distribution of a Solute Between Immiscible Liquids
Distribution Coefficient
Extraction with Immiscible Solvents
Countercurrent Extraction
Solutions of Liquids in Liquids
Determination of Solubility
Three Component Systems
Solutions of Gases in Liquids
Methods of Dissolving Gases
Solvents Used in Pharmacy
Mixed Solvents
Chapter 2
Ionization Constants
Buffer Solutions
Determination of pH Values
Electrometric Methods for Determining pH
Significance of pH in Pharmacy
Chapter 3
Polymorphism
Isomorphous Crystals
Mechanism of Crystallization
Crystal Growths in Suspensions
Precipitation
Fractional Crystallization
Water of Crystallization
Vapour Pressure of Hydrates
Exsiccation
Chapter 4
Metal Ion Complexes
Organic Molecular Complexes
InclusionOcclusion Compound Complexes
Analysis Methods for Determination of Complexes
Protein Binding
Applications of Complexation
Chapter 5
LiquidGas and LiquidLiquid Interfaces
Measurement of Surface and Interfacial Tension
Surfactants
Classification of Surfactants
Surface Activity
Bulk Properties of Surfactant Solutions
Structure of Micelles and Liquid Crystals
Solubilization
Insoluble Monolayers
LiquidSolid Interface
Adsorption on to Solids
Promotion of Wetting
Detergency
Water Repellenyc
Chapter 6
Lyophilic Colloids
Lyophobic Colloids
Association Colloids Amphiphilic Colloids
Preparation of Lyophobic Sols
Purification by Dialysis
Properties of Colloidal Systems
Precipitation of Lyophobic Colloids
Precipitation of Lyophobic Colloids
Stabilizing Effect of Lyophilic Colloids
Stability of Colloids
Gels
Pharmaceutical Applications of Colloids
Chapter 7
Types of Adsorption
Langmuir Adsorption Isotherm
Bet Adsorption Isotherm
Adsorption From Solution
Charcoals
Applications of Adsorption
Chapter 8
Adsorption Chromatography
Partition Chromatography
Paper Chromatography
ThinLayer Chromatography TLC
Gas Chromatography Vapour Phase Chromatography
Applications
Ion Exchange
Behaviour of Ion Exchangers
Applications
Medicinal Uses of Ion Exchange Resins
Height Equivalent to Theoretical Plate HETP
HighPerformance ThinLayer Chromatography HPTLC
HighPressure Liquid Chromatography HPLC
Chapter 9
Ficks Law of Diffusion
Measurement of Diffusion
Diffusion of Drugs from Dosage Forms
Theories of Dissolution
Design of Dissolution Apparatus
Chapter 10
Elastic Solids
Bulk Modulus
Measurement of Elasticity
Fluids
Viscosity Of Fluids
Flow Characteristics of Newtonian Fluids
Effect of Temperature
Determination of Viscosity
Creep Testing
Flow Properties of NonNewtonian Liquid
Rheology of Suspensions
Rheology of Emulsions
Rheology of Suspending Agents
Chapter 11
Chemical Degradation of Pharmaceutical Products
Physical Factors Influencing Chemical Degradation
Application of Chemical Kinetics to Decomposition of Pharmaceutical Products
Complexity of Kinetic Relationships Occurring in Some Pharmaceutical Products
Factors Influencing and Methods of Reducing Chemical Degradation
Physical Degradation of Pharmaceutical Products
Stability Testing
Chapter 12
History of ICH
Organization of ICH
The Qsem Concept
ZoneWise Distribution of Countries According to Ich Guidelines
Stability Programme for a New Drug
Steps of Analytical Development and Stability Testing
ICH QGuidelines Quality
Glossary
Abbreviations
Chapter 13
Leaching Processes
Equipments for Leaching Coarse Solids
OilSeed Extraction
Extraction of Fine Material
Continuous Leaching of Fine Solids
Liquid Liquid Extraction
Chapter 14
Theory
Equipments
Chapter 15
General Principles of Evaporation
SmallScale Methods
LargeScale Methods
Chapter 16
Simple Distillation Under Atmospheric Pressure
Simple Distillation Under Reduced Pressure
Fractional Distillation
Distillation in Steam
Chapter 17
Theoretical Considerations
Pretreatment of Materials
Methods of Filtration
Air Filtration
Chapter 19
Handling Properties
Chapter 20
Emulsions
Suspensions
Designing Preparation and Stabilization of Pharmaceutical Suspensions
Chapter 21
Tablets
Granulation
Production of Tablets
Tablet Coating
The Quality Control of Tablets
Theoretical Studies in Tabletting Technology
Capsules
Chapter 22
The International Pharmacopoeia
The European Pharmacopoeia
The British Pharmaceutical Codex
The British National Formulary
The Extra Pharmacopoeia
The United States Pharmacopoeia
Usp 34Nf 29 2011
Indian Pharmacopoeia
Medicines Legislation
Chapter 23
The Metric System
Liquid Measures
Analytical Balances and Weights
The Weighing Station
Weighing of Hygroscopic and Volatile Substances
Chapter 24
Expression of Strengths of Intravenous Fluids
Osmolarity and Osmolality
Calculation of Doses for Children
Chapter 25
Form of the Prescription
Language of Prescription Writing
Dispensing Routine
Hospital Prescriptions
Chapter 26
Solid Preparations
Emulsions
Chapter 27
Enemas
Chapter 28
Solid Preparations
Chapter 29
Eye Drops
Eye Lotions
Eye Ointments
Ocusert
Chapter 30
Parenteral Administration Routes
Formulation of Parenteral Products
Containers
Parenteral Dosage Forms
Chapter 31
Levels of Drug Targeting
Combination Targeting
Problems Associated with Targeted Delivery Systems
Liposomes
Chapter 32
Interaction of Radiation with Matter
Production of Radionuclides
Counting Instruments and the Detection of Radiation
Radiation Hazards and Radiological Safety
Radiochemical Applications
Chapter 33
Bacteria
Fungi
Protozoa
Nutrition and Energy Provision
Some Method of Microbiology
Microbial Growth and Reproduction
Energy Yielding Metabolism
Dna Functions and Some Cellular Control Mechanisms
Allosteric Control of Enzyme Activity
Microbial Diseases and Immunology
Chapter 34
Disinfectants
Disinfectant Evaluation
Chapter 35
Sterilization Processes
Gaseous Sterilization
Preparation of Sterile Medicaments
Chapter 36
Chapter 37
The Immune State
Immune Sera
Vaccines
Vaccines Used in Prophylaxis
Chapter 38
Antibiotic Research and Production
The Search for a New Antibiotic
Antibiotic Production
Antibiotic Assay
Penicillins
Cephalosporins
Chloramphenicol
Polypeptide Antibiotics
Carbohydrate Antibiotics
Tetracyclines
Erythromycin
Novobiocin
Fusidic Acid
Griseofulvin
Lincomycin
Clindamycin
Vancomycin
Rifampicin
Chapter 39
Concentrated Human Red Blood Corpuscles BP
Concentrates of Platelets and White Blood Corpuscles
Plasma Serum and Plasma Fractions
Coagulation Factors
Albumin Preparations
Human Albumin Purified
Plasma Substitutes
Chapter 40
Absorbable
Standards and Legal Requirements for Sutures and Ligatures
Absorbable Materials
Absorption of Catgut in the Body
Nonabsorbable Sutures
Surgical Needles
Chapter 41
Economic LargeScale Manufacture
Acceptability
Stability
Preservation Against Microbial Spoilage
Therapeutic Effectiveness
Chapter 42
Basic Aerosol Technology
Basic Aerosol Formulation
Chapter 43
Packaging Materials
Chapter 44
General Considerations
Solid Dosage Forms
Liquid Dosage Forms
Contract Manufacture
Index
Copyright

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