Benzodiazepine/GABA Receptors and Chloride Channels: Structural and Functional Properties
Richard W. Olsen, J. Craig Venter
A.R. Liss, 1986 - Benzodiazepines - 351 pages
The fifth volume in the series is the first to deal exclusively with a single type of receptor. Contributions represent the most up-to-date research in the benzodiazepine/GABA receptor-chloride channel complex, an extremely interesting protein of great neurobiological significance. Major workers in the field describe the history of GABA receptors and the benzodiazepine connection''. Lays out background material in a particularly clear fashion to allow readers from outside the field to quickly grasp the main points. Presents in detail the allosteric interactions between the various components of the benzodiazepine/GABA receptor complex from the points of view of several authors, so that readers can choose their level of involvement with these details. Includes the most recent advances on the biochemical purification, characterization, and development of monoclonal antibodies for the benzodiazepine/GABA receptor protein.
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Monoclonal Antibodies and Receptor Structure
Determination of Membrane Protein Concentration
18 other sections not shown
action activity affinity allosteric amino acid anions antagonist anxiolytic azepine baclofen barbiturates benzo benzodi benzodiaze benzodiazepine receptor bicuculline bicuculline-sensitive Biochem Bowery Braestrup brain membranes Brain Res cells ceptor cerebral cortex chloride channel chloride ion convulsants Curtis DR depolarization depressant diazepam diazepine drugs effect of GABA enhance Enna SJ flunitrazepam flurazepam function GABA agonists GABA and benzodiazepine GABA binding GABA recep GABA receptor GABAA GABAB GABAergic glutamate Haefely high-affinity hippocampal inhibition inhibitory interactions inverse agonists ionophore Johnston Karobath Krogsgaard-Larsen labeled Leeb-Lundberg ligands low-affinity mammalian modulation Möhler H molecular muscimol nervous system Neurochem neurons Neurosci neurotransmitter Olsen RW pentobarbital pharmacological photoaffinity labeling Physiol picrotoxin Polc postsynaptic potential protein purified rat brain receptor agonists receptor binding receptor complex responses SITBPS binding Snowman solubilized specific spinal cord Squires studies subunit Supavilai synaptic Takeuchi Tallman TBPS binding THIP Ticku MK tion tors transmitter uptake vitro vivo y-aminobutyric acid zodiazepine