Benzodiazepine Receptor Inverse Agonists
Martin Sarter, David J. Nutt, Richard G. Lister
Wiley, Jan 23, 1995 - Medical - 304 pages
Benzodiazepine Receptor Inverse Agonists Edited By Martin Sarter, David J. Nutt, and Richard G. Lister Discovered in the late 1970s and early 1980s, benzodiazepine receptor (BZR) inverse agonists have become the subject of intensive research because of their ability to modulate activity in neurotransmitter systems in a new manner. Benzodiazepine Receptor Inverse Agonists is the first comprehensive volume devoted to the pharmacology and psychopharmacology of these compounds. The chapters provide a contemporary and comprehensive overview of topics, ranging from receptor models developed to explain the neuronal effects of BZR inverse agonists, to the cognitive effects of particular inverse agonists in humans. Written by experts in the field and based on a decade of current research, this volume integrates basic receptor-related research, animal behavior pharmacology, and human psychopharmacological research to provide a complete overview of the topic. Benzodiazepine Receptor Inverse Agonists is invaluable for anyone working in the field of neuroscience, in particular pharmacology, psychopharmacology, behavioral pharmacology, behavioral neuroscience, psychobiology, neurophysiology, and neurobiology.
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3-carboline acetylcholine ACh efflux ACh release acid action activity administration affinity animals antagonize anxiety anxiogenic anxiolytic attenuated azepine basal forebrain benzodiazepine agonists benzodiazepine receptor benzodiazepine receptor agonists benzodiazepine receptor inverse benzodiazepine receptor ligands bicuculline binding sites block Braestrup BZR agonists BZR inverse agonists BZR ligands chlordiazepoxide cholinergic chronic treatment cognitive compounds convulsant cortex cortical ACh decrease diazepam discriminative stimulus DMCM doses drugs Duka effects of benzodiazepine effects of BZR effects of ethanol effects of inverse effects of Ro enhance ethanol flumazenil flunitrazepam function GABA GABAA receptor GABAergic hippocampus increase induced inhibition injection inverse agonist FG kindling lesions ligands Lister RG memory mg/kg mice modulation neurons Neurosci NMDA Nutt DJ partial inverse agonist pentylenetetrazole Pharmacol Biochem Behav pharmacological Photoaffinity labeling placebo potential properties Psychopharmacology receptor complex receptor inverse agonists response Sarter scopolamine sensitivity Sieghart Stephens DN stimulation studies transmission Turski vivo zodiazepine zolpidem