This volume surveys the chemistry and cancer-causing properties of the polycyclic hydrocarbons benzo[a]pyrene and benzo[e]pyrene. Benzo[a]pyrene is a pollutant formed whenever organic matter is burnt: it occurs in soot, tar, cigarette smoke and automobile exhaust, and in small amounts in the atmosphere, in water and in soil. It produces cancer in small mammals and is probably also carcinogenic in humans. It has been widely studied both as a measure of industrial pollution and as a model compound in studies of the mechanism of induction of cancer. Information about the compound is scattered through the scientific literature in various journals, conference proceedings and other publications; this book is the first to gather all this information together for easy reference. It includes chapters on the synthesis, physical and chemical properties of benzopyrene, its metabolism, interaction with DNA and induction of mutation and cancer, and also its environmental occurrence and analysis. There are copious references to the original literature. The volume will provide a valuable source of reference for: cancer reseach scientists; environmental scientists working in the area of pollution monitoring, public health, industrial safety, food and drugs; chemists and biochemists.
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Binding to proteins and nucleic acids
Detection of bound Bap in DNA
Principal methods of testing for carcinogenicity
9-hydroxy-BaP acid activity adducts alkylation Amer analysis analytical anti-BaPDE BaFDE BaP derivatives BaP metabolism BaP-7,8-dihydrodiol BaPDE benzopyrenes binding of BaP binding to DNA Biochem Biophys bond Cancer Cancer Res Carcinogenesis carcinogenic Cavalieri cells Chem Chem.-Biol chemical Chromatogr chromatography column concentration conjugates Conney covalent Daub detected dihydrodiol diol diol-epoxide eluted emission enantiomers enzyme epoxide epoxide hydrolase extraction Fieser fluorescence Gelboin glucuronide glutathione Grimmer Grover hamster Harvey HPLC hydrolysis hydroxyl incubation Interact isomers Jerina Jernström K-region Levin lung metabolism of BaP metabolites methanol methods methyl mice microsomes mixture molecular molecule mouse skin mutagenic mutation Natl nuclei nucleoside Oesch oxidation PAH compounds phenols polycyclic aromatic hydrocarbons polycyclic hydrocarbons Polynuclear Aromatic Hydrocarbons protein pyrene quinones rat liver microsomes reaction reactive samples Selkirk separation silica Sims Slaga solution solvent spectra spectrum syn-BapDE synthesis Table technique Thakker tritiated tritium tumours vitro Yagi