Benzopyrenes

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CUP Archive, Jun 18, 1987 - Medical - 329 pages
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This volume surveys the chemistry and cancer-causing properties of the polycyclic hydrocarbons benzo[a]pyrene and benzo[e]pyrene. Benzo[a]pyrene is a pollutant formed whenever organic matter is burnt: it occurs in soot, tar, cigarette smoke and automobile exhaust, and in small amounts in the atmosphere, in water and in soil. It produces cancer in small mammals and is probably also carcinogenic in humans. It has been widely studied both as a measure of industrial pollution and as a model compound in studies of the mechanism of induction of cancer. Information about the compound is scattered through the scientific literature in various journals, conference proceedings and other publications; this book is the first to gather all this information together for easy reference. It includes chapters on the synthesis, physical and chemical properties of benzopyrene, its metabolism, interaction with DNA and induction of mutation and cancer, and also its environmental occurrence and analysis. There are copious references to the original literature. The volume will provide a valuable source of reference for: cancer reseach scientists; environmental scientists working in the area of pollution monitoring, public health, industrial safety, food and drugs; chemists and biochemists.
 

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Contents

Synthesis
10
From benzanthrenes
16
Physical properties
23
Theoretical chemistry
31
Chemistry
37
13
48
Derivatives
52
23
54
Hydrolysis
113
37
119
39
129
References
130
Binding to proteins and nucleic acids
137
Detection of bound Bap in DNA
143
Ames test
177
Principal methods of testing for carcinogenicity
198

Phenols
60
1Acetyl
66
26
68
Metabolism
73
Separation of metabolites
79
Substances affecting BaP metabolism
93
34
99
Diolepoxides
107
Benzoepyrene
229
Binding to
243
Liquidliquid partition
275
Occurrence of benzopyrenes in the environment
301
Further reading
317
229
326
304
329
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