Bile Acids in Gastroenterology: Basic and Clinical Advances
A.F. Hofmann, G. Paumgartner, A. Stiehl
Springer Science & Business Media, Jun 30, 1995 - Medical - 402 pages
This book contains the proceedings of the XIIIth International Bile Acid Meeting (Falk Symposium 80), an official satellite meeting of the World Congress of Gastroenterology, held in San Diego, California, U.S.A., September 30--October 2, 1994.
It begins with presentations of major advances in bile acid chemistry, biology and pharmacology. The new structure proposed for the mixed micelles present in bile is reviewed, as are the properties of new synthetic analogues of bile acids. The mechanisms by which bile acids interact with cell membranes are discussed in order to provide insight into the hepatotoxic effects of bile acids in cholestatic liver disease.
The book further shows the exciting progress in the molecular biology of bile acid transport by the hepatocyte and enterocyte, and concludes with a consensus on the use of ursodeoxycholic acid in cholestatic liver disease and as an adjunct to immunosuppressive therapy after liver transplantation, and to interferon therapy in chronic viral hepatitis.
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a-OH absorption bilayer bile acid biosynthesis bile acid synthesis bile acid transport bile acids bile flow bile salts biliary lipid secretion Biochem Biol Chem Ca2+ canalicular canalicular membrane Carey MC CDCA cells chenodeoxycholic acid cholestasis cholestatic cholesterol 7a-hydroxylase mRNA cholyltaurine chronic Clin Invest colonic concentration CYP7 cytosolic decrease deoxycholic effect of ursodeoxycholic enterohepatic circulation enzyme excretion gallbladder gallstone Gastroenterology GCDC hamster hepatic hepatocytes Hepatology human hydrophilic hydrophobic hydrophobic bile acids hydroxyl increase infusion inhibition inhibitors isolated lecithin Lipid Res liver disease mechanism metabolism micelles mitochondrial mixed micelles mmol/l molecular mRNA mRNA levels organic anions pathway PC-TP perfused phosphatidylcholine phospholipid phospholipid secretion photoaffinity labelling Physiol primary bile acids primary biliary cirrhosis protein kinase rat hepatocytes rat liver reductase regulation of cholesterol Roda serum Setchell KDR solubility solutions steroid sterol Stiehl studies taurocholate therapy transcriptional activity treatment UDCA uptake ursodeoxycholic acid ursodiol vesicles vitro