BioNMR in Drug Research
John Wiley & Sons, Mar 6, 2006 - Science - 502 pages
The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt WŁthrich. Edited by a former coworker of WŁthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids.
BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies.
With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.
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15N-labeled alignment amide proton amino acid anisotropy applied assignment atoms backbone binding Biochemistry Biol biological Biomol bound Chapt Chem chemical shift coherence complex components compounds conformation correlation coupling constants cross peaks cross-correlated cross-correlated relaxation decoupling detection deuteration drug dynamics exchange experimental expression filtering fragments frequency GRzEsIEK H-bond heteronuclear homonuclear HSQC hydrogen bond intein interactions isotope labeling J-coupling Lett ligand Magn measured membrane ment methods micelles molecular molecules Natl NMR experiments NMR screening NMR spectroscopy NOESY nucleic acids observed obtained orientation paramagnetic parameters peptide Phys polarization protein protons pulse sequence receptor relaxation rates residual dipolar couplings Reson sample scalar coupling second-site sensitivity side chains signals solid-state NMR solubility spectra spectroscopy spectrum spin label structural information structure calculation structure determination target techniques temperature tensor tion torsion angle transfer transverse relaxation trNOE TROSY values vectors WUTHRICH