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JAMES R GILLETTE
Cellular Defense Mechanisms against Reactive Metabolites
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2,5-hexanedione 3-methylcholanthrene acetaminophen acetylenic adducts alkylation amines anion arene oxides aromatic hydrocarbons arylamines atom bay region diol benzene benzo[a]pyrene bioactivation Biochem Biol biological Biophys blood bond Cancer Res carbon tetrachloride carcinogenesis carcinogenic catalyzed catechols cells cellular Chem chemically reactive metabolite chloride compartment concentration Conney covalent binding cysteine cytochrome P-450 derivatives dihydrodiols diol Drug effects electron electrophilic enzymatic enzyme epoxide hydrolase first-pass formation formed free radicals furan glutathione S-transferase halogenated heme hepatic hepatocytes hydrazines hydroxylation inhibition Interact Jerina kinetic Levin lipid liver mechanism metabolic activation metabolism metabolites methyl mice microsomal Miller misonidazole mouse mutagenic NADPH Natl nitrosamines nucleophilic olefins organ oxidation oxygen PAHs parent compound pathway peroxidation Pharmacol phenols polycyclic aromatic Proc protein quinones rat liver microsomes reaction reactive intermediates reduction region diol epoxides role studies substitution substrate Thakker thiols tion tissue toxicity Toxicol tumorigenic tumors vinyl vitro vivo Yagi