Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development

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Edith Mathiowitz, Donald E. Chickering III, Claus-Michael Lehr
CRC Press, Jul 13, 1999 - Medical - 696 pages
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This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs.
Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport!
Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems
  • discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology
  • analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces
  • covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions
  • examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles
  • describes vaginal, nasal, buccal, ocular, and transdermal drug delivery
  • reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts
  • explores issues of product development, clinical testing, and production
  • and more!
    Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.
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    Contents

    Definitions Mechanisms and Theories of Bioadhesion
    1
    The Role of Water Movement and Polymer Hydration in Mucoadhesion
    11
    A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels
    25
    Functional Histology of Epithelia Relevant for Drug Delivery Respiratory Tract Digestive Tract Eye Skin and Vagina
    67
    Biochemical and Functional Aspects of Mucus and MucinType Glycoproteins
    85
    Adaptation of a Microbalance to Measure Bioadhesive Properties of Microspheres
    131
    Novel Magnetic Technique to Measure Bioadhesion
    147
    Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems
    175
    Plant Lectins for Oral Drug Delivery to Different Parts of the Gastrointestinal Tract
    389
    Bacterial Invasion Factors and Lectins as SecondGeneration Bioadhesives
    411
    Novel PEGContaining Acrylate Copolymers with Improved Mucoadhesive Properties
    435
    Bioadhesive Bioerodible Polymers for Increased Intestinal Uptake
    461
    Novel Formulation Approaches to Oral Mucoadhesive Drug Delivery Systems
    479
    Bioadhesive Formulations for Nasal Peptide Delivery
    509
    Development of Bioadhesive Buccal Patches
    543
    Vaginal Delivery of Calcitonin by Hyaluronic Acid Formulations
    565

    Force Microscopy of Cells to Measure Bioadhesion
    197
    Direct Measurement of MolecularLevel Forces and Adhesion in Biological Systems
    223
    A Centrifugation Method for Measurement of TwoDimensional Binding Characteristics of ReceptorLigand Interaction
    261
    Multifunctional Polymers for the Peroral Delivery of Peptide Drugs
    301
    Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia
    343
    Ocular Bioadhesive Drug Delivery Systems
    603
    Bioadhesive Preparations as Topical Dosage Forms
    643
    Index
    661
    Copyright

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