Bioavailability of Drugs to the Brain and the Blood-brain BarrierU.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, 1992 - Medical - 265 pages |
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abluminal activity addiction albumin amino acid antibody astrocytes Audus AZT-CDS Balin BBB permeability Betz binding Biol blood flow blood-borne blood-brain barrier Bodor Borchardt bovine brain microvessel brain capillary endothelial brain ECs brain microvessel endothelial brain parenchyma Brain Res brain uptake Brightman Broadwell Broadwell 1989 capillary endothelial cells carotid cationized cerebral chimeric peptide choroid plexus circumventricular organs cocaine compounds concentration conjugate cultured cultured brain demonstrated dose DRUG ABUSE drug delivery effects endocytic endocytosis endosomes endothelial cells endothelium enzymes extracellular fenestrated Fenstermacher figure fluid fluid-brain barriers glucose Goldstein GPO Stock grafts Harik injection lipid lipophilicity luminal lysosomes macromolecules membrane metabolism microvessel endothelial cells molecules monoamine monolayers MPP+ MPTP Neurochem neurons Neurosci neurotransmitter Neuwelt nicotine NTIS PB Oldendorf opioid peptides Pardridge perfused perivascular peroxidase Ph.D Pharmacol Physiol plasma protein radiolabeled Rapoport rat brain receptor receptor-mediated studies surface tight junctions tissue transcytosis transferrin treatment vesicles vessels vitro vivo Zlokovic