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Diagnosis of Metabolic Bone Disease
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abnormal absorption acid activity adult alkaline phosphatase appearance biochemical biochemistry biopsy bone formation bone loss bone mass bone matrix bone resorption calcification calcinosis calcitonin calcium cause Chapter Clin clinical features collagen commonest connective tissue defect deformity demonstrate Dent diagnosis diphosphonates disease of bone disorders of connective doses dwarfism dysplasia ectopic effects EHDP enzyme evidence excessive excretion Figure fractures growth histological homocystine homocystinuria hydroxyproline hypercalcaemia hypophosphataemic hypophosphatasia idiopathic important increased inherited Jowsey Lancet long bones Marfan's syndrome McKusick measurements metabolic bone disease metabolites mineral mucopolysaccharides muscle Nordin normal occur oestrogens ossification osteoblasts osteocytes osteogenesis imperfecta osteoid osteomalacia osteoporosis Paget's disease pain parathyroid hormone patients plasma alkaline phosphatase plasma calcium plasma phosphate primary hyperparathyroidism produce protein radiological reduced renal failure renal osteodystrophy renal-tubular rickets sclerae scoliosis severe osteogenesis imperfecta short stature skeletal skeleton skin Smith suggest symptoms treatment tumour Type urinary vertebral vitamin vitamin D deficiency