Biochemical Messengers: Hormones, Neurotransmitters and Growth Factors

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Springer Science & Business Media, May 1, 1991 - Science - 311 pages
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The main argument of this book is that cell signalling via nerves, hormones, local mediators and growth factors are not distinct phenomena, but branches of one general mechanism and should therefore be studied in an integrated manner. This volume is designed to act as a bridge between general texts and is aimed at biologists coming to the topic from a variety of backgrounds. The first two chapters introduce the general concepts of intracellular signalling and also cover the topic of direct cell-to-cell communication by cytoplasmic bridges (gap junctions). The remaining chapters cover the first and second messengers, starting with their structure, synthesis and release, progressing to the target cell and then working from the membrane inwards towards the nucleus. There is also a section on the mechanism of nervous conduction and the regulation of the ionic balace of cells. The final chapters discuss the regulation of cell growth and division and the special case of messengers acting via nuclear receptors.

 

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Contents

The first messengers hormones neurotransmitters and local
21
Structure and biosynthesis of first messengers
45
Ionic homeostasis and nervous conduction
71
Cell biology of first messenger synthesis and secretion
93
Cell surface receptors analysis and identification
109
Cell surface receptors signal transduction
147
Cell surface receptors protein phosphorylation and other
191
Regulation of cell proliferation and cancer
249
Signal transduction by nuclear receptors
279
Appendix
295
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Page 276 - Ullrich, A., Coussens, L., Hayflick, JS, Dull, TJ, Gray, A., Tarn, AW, Lee, J., Yarden, Y., Libermann, TA, Schlessinger, J., Downward, J., Mayes, ELV, Whittle, N.. Waterfield, MD, and Seeburg, PH, 1984, Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells, Nature 309:418-425.

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Medical Biochemistry
N Mallikarjuna Rao
No preview available - 2006
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