Biochemical studies on the sigma-1 receptor: a multidrug binding protein of enigmatic function

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University of Wisconsin--Madison, 2008 - 220 pages
The sigma-1 receptor is an ubiquitously expressed transmembrane protein, notable for its ability to bind a variety of pharmacological agents. Although certain steroids bind to the sigma-1 receptor, a small endogenous molecule that regulates the activity of this receptor has not been identified. The sigma-1 receptor has been shown to have chaperone activity, modulate voltage gated ion channels, modulate Ca2+ release through the endoplasmic reticulum and promote the growth of cancer cells. The sigma-1 receptor does not display any homology to known mammalian proteins but shares homology with the steroid enzyme C8- C7 sterol isomerase from yeast.

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Contents

1 Photoprobes used in the identification of the sigma1 receptor
5
3 Pharmacophore for high affinity binding to the sigma1 receptor
11
4 Sequence Alignment of sigma1 receptor from different species
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