Biodefence Mechanisms Against Environmental Stress

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Toshihiko Ozawa, Kouichi Tatsumi, Tada-aki Hori
Kodansha, Jan 1, 1998 - Science - 192 pages
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All living cells have developed a network of biodefence systems to protect themselves against the effects of various environmental stress factors. Besides direct effects on DNA, active oxygens and free radicals are believed to cause funtional defects in living organisms by affecting the signal transduction associated with the activation of specific genes. This can, in turn, lead to cancer and premature aging. This book reviews the five main topics: 1. Protection against oxidative stress-induced damages, 2. Signal transduction systems for biodefence, 3. Apoptosis as a biodefence mechanism, 4. Radiation-induced DNA damage, repair and mutagenesis, 5. Repair of UV-induced DNA damage.

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Contents

In Vivo ESR Measurement of Free Radical Reactions in Living Mice
13
A Metabolic Antioxidant and Redox Modulator of Signal
33
Regulatory Mechanisms of Gene Activation Induced by DNA Damage
49
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