Biodefence Mechanisms Against Environmental Stress
Toshihiko Ozawa, Kouichi Tatsumi, Tada-aki Hori
Kodansha, Jan 1, 1998 - Science - 192 pages
All living cells have developed a network of biodefence systems to protect themselves against the effects of various environmental stress factors. Besides direct effects on DNA, active oxygens and free radicals are believed to cause funtional defects in living organisms by affecting the signal transduction associated with the activation of specific genes. This can, in turn, lead to cancer and premature aging. This book reviews the five main topics: 1. Protection against oxidative stress-induced damages, 2. Signal transduction systems for biodefence, 3. Apoptosis as a biodefence mechanism, 4. Radiation-induced DNA damage, repair and mutagenesis, 5. Repair of UV-induced DNA damage.
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In Vivo ESR Measurement of Free Radical Reactions in Living Mice
A Metabolic Antioxidant and Redox Modulator of Signal
Regulatory Mechanisms of Gene Activation Induced by DNA Damage
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Acad administration amino acids antioxidants apoptosis apoptotic Biochem biodefence Biol biological Biophys brain cancer carbamoyl-PROXYL catechin cDNA cellular ceramide Chem Chiba clones complex concentration DHLA dihydrolipoate DMPO-OH DNA binding DNA fragmentation DNA glycosylase DNA repair DNase dose endonuclease ERCC1 Fpg protein free radical G-lipoate genetic Genome Research Group glutathione hepatitis homologous homologous recombination hydroxy-TEMPO hydroxyl radical indicate induced inhibited injection intracellular irradiation ischemia Japan kinase lipid peroxidation lipoate mammalian cells mechanisms membrane mg/kg mice molecular mouse mutations Natl neuronal death NF-kB NF-kB activation NIRS nitroxyl nitroxyl radicals O-lipoic acid observed oxidative oxygen species Packer pathway PBN-administered peptides PHCKRM pombe pretreatment Proc protective effects protein radiation radiation-induced rats reaction recombination redox reduction region Rooibos Rooibos tea scavenging ability sequence signal signal transduction silent mutations spin-probes stress superoxide TBARS thiols thymocytes tissues transcription tumors Utsumi vitamin vitro vivo yeast