Biofilms in Medicine, Industry and Environmental Biotechnology
Piet Lens, V. O'Flaherty, A. P. Moran, P. Stoodley, T. Mahony
IWA Publishing, Apr 30, 2003 - Science - 608 pages
Biofilms are of great practical importance for beneficial technologies such as water and wastewater treatment and bioremediation of groundwater and soil. In other settings biofilms cause severe problems, for example in 65% of bacterial infections currently treated by clinicians (particularly those associated with prosthetics and implants), accelerated corrosion in industrial systems, oil souring and biofouling. Until recently, the structure and function of biofilms could only be inferred from gross measures of biomass and metabolic activity. This limitation meant that investigators involved in biofilm research and application had only a crude understanding of the microbial ecology, physical structure and chemical characteristics of biofilms. Consequently, opportunities for the exploitation and control of biofilms were very limited. The past decade has witnessed the development of several new techniques to elucidate the structure and function of biofilms. Examples include: the use of molecular probes that identify different microbes in complex communities as well as their metabolic functions; the use of microsensors that show concentration gradients of key nutrients and chemicals; the use of confocal laser scanning microscopy to describe the physical structure of biofilms and the development of a new generation of mathematical models that allow for the prediction of biofilm structure and function. However, much progress remains to be made in efforts to understand, control and exploit biofilms. This timely book will introduce its readers to the structure and function of biofilms at a fundamental level as determined during the past decade of research, including: Extracellular polymers as the biofilm matrix; Biofilm phenotype (differential gene expression, interspecies signalling); Biofilm ecology; Biofilm monitoring; Resistance of biofilms to antimicrobial agents and Biofilm abatement. Biofilms in Medicine, Industry and Environmental Technology offers a holistic and multi-disciplinary description of the topic, including biofilm formation and composition, but also biofilm monitoring, disinfection and control. All these aspects are presented from three points of views: medical, industrial and environmental biotechnological in a compact, easy to read format.
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acid actinomyces activity adhesin adhesion aerosol anaerobic antibiotic antimicrobial Appl attachment aureus bacteria Bacteriol bacterium bioaerosols biocides BIOFILM bioﬁlm development bioﬁlm formation bioﬁlm growth bioﬁlm matrix bioﬁlm structure biofouling biological biomass Biotechnol cell surface cell type chemical coaggregation coefﬁcient coli concentration corrosion Costerton deﬁned difﬁcult diffusion disinfectants electrode Environ environmental enzymes Escherichia coli etal exopolymers extracellular polymeric substances ﬁeld Figure ﬁlm ﬁlter ﬁrst Flemming ﬂow cells ﬂuid ﬂuorescence gene gradient gradostat Gram-negative granules hybridisation hydrophobic imaging infection inﬂuence interactions layer lectins measurements mechanisms membrane methanogenic microbial microbial cells Microbiol Microbiology microelectrode microorganisms microscopy microsensors molecules monitoring monocytogenes mutants nutrient organisms oxide oxygen particles planktonic polymers polysaccharides probes proﬁles protein protozoa Pseudomonas aeruginosa quorum sensing reactor resistance role sample sensor signiﬁcant sludge species speciﬁc Stoodley strains Streptococcus studies substrate substratum techniques Technol tion UASB wastewater Water Sci Wimpenny Wingender