Bioinformatics: Genomics and Post-Genomics

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John Wiley & Sons, Jan 11, 2007 - Science - 252 pages
1 Review
This book is an excellent introductory text describing the use of bioinformatics to analyze genomic and post-genomic data. It has been translated from the original popular French edition, which was based on a course taught at the well-respected École Polytechnique in Palaiseau. This edition has been fully revised and updated by the authors.

After a brief introduction to gene structure and sequence determination, it describes the techniques used to identify genes, their protein-coding sequences and regulatory regions. The book discusses the methodology of comparative genomics, using information from different organisms to deduce information about unknown sequences. There is a comprehensive chapter on structure prediction, covering both RNA and protein. Finally, the book describes the complex networks of RNA and protein that exist within the cell and their interactions, ending with a discussion of the simulation approaches that can be used to model these networks.

Praise from the reviews:

“In context of the new developments the genomic era has brought, Bioinformatics: Genomics and Post-Genomics becomes a fundamental and indispensable resource for undergraduate and early graduate students…insightfully authored…will immensely help students…in establishing important foundations while shaping their careers.” NEWSLETTER, BRITISH SOCIETY OF CELL BIOLOGY


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Preface to the English edition
Genome sequencing
Sequence comparisons
Comparative genomics
Genetic information and biological sequences
Statistics and sequences
Structure prediction
Transcriptome and proteome macromolecular networks
Simulation of biological processes in the genome context

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About the author (2007)

Frédéric Dardel. LCRB - UMR8015 CNRS, Faculté de Pharmacie, Université René Descartes/Paris.

François Képès. Epigenomics Project, Genopole®, Bldg G3, 93 rue Henri Rochefort, 91000 Evry, France.

Translated by Noah Hardy.

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