Bioinformatics: sequence and genome analysis
As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.
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algorithm alignment score amino acid amino acid substitution base pairs Bioinformatics Biol biological BioPerl BLAST blocks calculated cDNA changes chromosome clusters codon column database search database sequence Dayhoff described in Chapter distance DNA sequences domains dynamic programming eukaryotic evolutionary example exons FASTA frequency function gap penalties GenBank gene expression gene prediction genetic genome sequence global alignment hidden Markov model identify introns large number length log odds scores matches ment method microarray modules motif mRNA multiple sequence alignment mutation Nucleic Acids Res organism output Perl phylogenetic analysis probability produce protein families protein sequences protein structure proteome PSSM query sequence regions related sequences represent residues sample scoring matrix script secondary structure sequence analysis sequence database sequence positions sequence similarity server similarity searches statistical structure prediction substitution matrices Table tein tion tree variable