Bioinformatics: from genomes to drugs, Volume 1
Bioinformatics - the use of computers to retrieve, process, analyze and simulate biological information - promises to revolutionize the process of drug discovery and development. This book provides a broad, application-oriented overview of this technology. Contributions by internationally renowned specialists in the field afford a detailed insight into single bioinformatics components and algorithmic methods. In addition, the state-of-the-art in bioinformatics is evaluated equally from a global view by introducing real application scenarios such as genome projects that require the use of a whole set of bioinformatics tools.
The profound knowledge on bioinformatics presented here not only enables readers to go beyond a mere push-button approach to using bioinformatics software and interpreting the data generated appropriately. It is also essential to assess the potential and limitations of today's bioinformatics software and future challenges. Directed to all those involved in the use or development of new bioinformatics tools - scientists and managers from the fields of molecular biotechnology, pharmaceutics, and medicinal chemistry - this book will lead one step further on the way to rational drug design
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From Genomes to Drugs with Bioinformatics
New analysis methods 176
Bioinformatics Support of Genome Sequencing Projects
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Acad acceptor accuracy amino acids analysis annotation approach atoms backbone binding sites bioinformatics biological calculated cell clusters coding regions combinatorial complex conformations consensus conserved core promoter database detection developed dihedral distance DNA sequences docking algorithms domains dynamic programming elements energy eukaryotic evaluation exons experimental Fgenesh flexible fold recognition fragments gene prediction genetic genomic sequences hidden Markov models homology modeling human inhibitor interactions intron ligand loops matching matrix Mol Biol molecular docking molecules multiple alignment Natl neural network Nucleic Acids Res nucleotides optimal pairs position potential prediction methods problem Proc procedure protein folding protein sequence protein structure prediction protein-ligand protein-protein protein-protein docking regulatory regions residues rigid-body rmsd rotamer scoring function secondary structure prediction sequence alignment side chains signal similarity simulated annealing Solovyev specific splice sites statistical target protein target sequence TATA box template structure threading tion