Bioinformatics: from genomes to drugs, Volume 1
Bioinformatics - the use of computers to retrieve, process, analyze and simulate biological information - promises to revolutionize the process of drug discovery and development. This book provides a broad, application-oriented overview of this technology. Contributions by internationally renowned specialists in the field afford a detailed insight into single bioinformatics components and algorithmic methods. In addition, the state-of-the-art in bioinformatics is evaluated equally from a global view by introducing real application scenarios such as genome projects that require the use of a whole set of bioinformatics tools.
The profound knowledge on bioinformatics presented here not only enables readers to go beyond a mere push-button approach to using bioinformatics software and interpreting the data generated appropriately. It is also essential to assess the potential and limitations of today's bioinformatics software and future challenges. Directed to all those involved in the use or development of new bioinformatics tools - scientists and managers from the fields of molecular biotechnology, pharmaceutics, and medicinal chemistry - this book will lead one step further on the way to rational drug design
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From Genomes to Drugs with Bioinformatics
Bioinformatics Support of Genome Sequencing Projects
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2-DE gels 2-DE images algorithm alignment allele amino acid annotated Appel R. D. approach assay assembly program automated Bairoch binding bioinformatics biological candidate CAP3 clustering complex constraints contain contig databank described detection disease DNA segment DNA sequence docking drug target electrophoresis EMBL entry enzyme ExPASy experimental expression patterns field Figure function GENBANK gene expression genetic genome sequencing genotyping Hochstrasser D. F. human genome inhibitors interactions large number ligand linkage disequilibrium markers mass spectrometry meta definition molecules mutations Nucleic Acids Res nucleotide overlap between reads peptide mass fingerprinting performed phenotype post-translational modifications protein identification protein sequence proteomics PTMs quality values query rank reads fx receptor regions sample score segment pairs selected sequence assembly sequence databases server Shannon entropy shotgun sequencing similar single nucleotide single-nucleotide polymorphisms SNPs specific strategy structure SWISS-PROT tion variation virtual screening