Bioinformatics of Genome Regulation and Structure II

Front Cover
Nikolay Kolchanov, Ralf Hofestädt, Luciano Milanesi
Springer Science & Business Media, Jun 15, 2006 - Science - 560 pages
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The last 15 years in development of biology were marked with accumulation of unprecedentedly huge arrays of experimental data. The information was amassed with exclusively high rates due to the advent of highly efficient experimental technologies that provided for high throughput genomic sequencing; of functional genomics technologies allowing investigation of expression dynamics of large groups of genes using expression DNA chips; of proteomics methods giving the possibility to analyze protein compositions of cells, tissues, and organs, assess the dynamics of the cell proteome, and reconstruct the networks of protein-protein interactions; and of metabolomics, in particular, high resolution mass spectrometry study of cell metabolites, and distribution of metabolic fluxes in the cells with a concurrent investigation of the dynamics of thousands metabolites in an individual cell. Analysis, comprehension, and use of the tremendous volumes of experimental data reflecting the intricate processes underlying the functioning of molecular genetic systems are unfeasible in principle without the systems approach and involvement of the state-of-the-art information and computer technologies and efficient mathematical methods for data analysis and simulation of biological systems and processes. The need in solving these problems initiated the birth of a new science— postgenomic bioinformatics or systems biology in silico.
 

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Contents

PREDICTING sRNA GENES IN THE GENOME OF E COL
11
THE SITEGA TOOL FOR RECOGNITION AND CONTEXT ANALYSIS
30
GENOMES
130
CHANGE IN CpG CONTEXT IS A LEADING CAUSE
147
NEW METHODS TO INFER DNA FUNCTION FROM SEQUENCE
165
REVELATION AND CLASSIFICATION OF DINUCLEOTIDE
178
MINING FROM COMPLETE PROTEOMES TO IDENTIFY ADHESINS
207
x
417
HYBRIDIZATION ON MICROARRAYS
451
DETERMINATION OF THE DEVELOPMENTAL
467
TOPICAL CLUSTERING OF BIOMEDICAL ABSTRACTS
481
SOFTWARE FOR ANALYSIS OF GENE REGULATORY SEQUENCES
491
A MATHEMATICAL MODEL OF TIIE DISCONTINUOUS GENETIC
499
1
517
3
538
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